Prevalence and Determinants of Hepatitis Delta Virus Infection Among HIV/Hepatitis B-Coinfected Adults in Care in the United States

Details

• Alternative Title:
  J Viral Hepat
• Personal Author:
  Ferrante, Nicole D. ; Kallan, Michael J. ; Sukkestad, Sophia ; Kodani, Maja ; Kitahata, Mari M. ; Cachay, Edward R. ; Bhattacharya, Debika ; Heath, Sonya ; Napravnik, Sonia ; Moore, Richard D. ; Yendewa, George ; Mayer, Kenneth H. ; Reddy, K. Rajender ; Hayden, Tonya ; Kamili, Saleem ; Martin, Jeffrey N. ; Kim, H. Nina ; Lo Re, Vincent
• Description:
  Hepatitis delta virus (HDV) infection increases the risk of liver complications compared to hepatitis B virus (HBV) alone, particularly among persons with human immunodeficiency virus (HIV). However, no studies have evaluated the prevalence or determinants of HDV infection among people with HIV/HBV in the US. We performed a cross-sectional study among adults with HIV/HBV coinfection receiving care at eight sites within the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) between 1996 and 2019. Among patients with available serum/plasma specimens, we selected the first specimen on or after their initial HBV qualifying test. All samples were tested for HDV IgG antibody and HDV RNA. Multivariable log-binomial generalized linear models were used to estimate prevalence ratios (PRs) with 95% CIs of HDV IgG antibody-positivity associated with determinants of interest (age, injection drug use [IDU], high-risk sexual behaviour). Among 597 adults with HIV/HBV coinfection in CNICS and available serum/plasma samples (median age, 43 years; 89.9% male; 52.8% Black; 42.4% White), 24/597 (4.0%; 95% CI, 2.4%-5.6%) were HDV IgG antibody-positive, and 10/596 (1.7%; 95% CI, 0.6%-2.7%) had detectable HDV RNA. In multivariable analysis, IDU was associated with exposure to HDV infection (adjusted PR = 2.50; 95% CI, 1.09-5.74). In conclusion, among a sample of adults with HIV/HBV coinfection in care in the US, 4.0% were HDV IgG antibody-positive, among whom 41.7% had detectable HDV RNA. History of IDU was associated with exposure to HDV infection. These findings emphasize the importance of HDV testing among persons with HIV/HBV coinfection, especially those with a history of IDU.
• Subjects:
  Adult Coinfection Cross-Sectional Studies Female Hepatitis Antibodies Hepatitis B Hepatitis B Virus Hepatitis Delta Virus HIV HIV Infections Humans Immunoglobulin G Male Prevalence RNA United States

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• Keywords:
  Epidemiology Hepatitis Delta Virus HIV HBV And HDV Coinfection
• Source:
  J Viral Hepat. 30(11):879-888
• Pubmed ID:
  37488783
• Pubmed Central ID:
  PMC10592429
• Document Type:
  Journal Article
• Funding:
  P30 AI094189/AI/NIAID NIH HHSUnited States/ ; U01 DA036935/DA/NIDA NIH HHSUnited States/ ; T32 DK007740/DK/NIDDK NIH HHSUnited States/ ; P30 AI045008/AI/NIAID NIH HHSUnited States/ ; R24 AI067039/AI/NIAID NIH HHSUnited States/ ; R21 AI124868/AI/NIAID NIH HHSUnited States/ ; P30 AI027763/AI/NIAID NIH HHSUnited States/ ; P30 AI050410/AI/NIAID NIH HHSUnited States/ ; CC/CDC HHSUnited States/
• Volume:
  30
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5390897153347e6e3692022e673ee232494fc4fa4c16c379832c2430130f0038bfcbb9977474cd6a9ea6b7536dd8d67787072f519250eaa3e73c751d2277938f
• Download URL:
  https://stacks.cdc.gov/view/cdc/134537/cdc_134537_DS1.pdf
• File Type:
  [PDF - 429.53 KB ]