Beijing/W Genotype Mycobacterium tuberculosis and Drug Resistance

Details

• Alternative Title:
  Emerg Infect Dis
• Corporate Authors:
  European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis
• Description:
  Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.
• Subjects:
  Adult Antitubercular Agents Communicable Diseases, Emerging Drug Resistance, Multiple, Bacterial Female Genotype Global Health Humans Male Middle Aged Mycobacterium Tuberculosis Prevalence Research Tuberculosis Tuberculosis, Multidrug-Resistant

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• Source:
  Emerg Infect Dis. 12(5):736-743.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:2d39f7c0b16f89107037c9ad3d18f29a5ab09be9f0045222753700ecae75abaa
• Download URL:
  https://stacks.cdc.gov/view/cdc/15896/cdc_15896_DS1.pdf
• File Type:
  [PDF - 228.36 KB ]