Welcome to CDC stacks |
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
Risk Factors for and Trends in Isoniazid Monoresistance at Diagnosis of Tuberculosis—United States, 1993-2016
  • Published Date:
    October 31 2019
  • Source:
    J Public Health Manag Pract.
  • Language:
    English


Public Access Version Available on: April 30, 2021, 12:00 AM information icon
Please check back on the date listed above.
Details:
  • Alternative Title:
    J Public Health Manag Pract
  • Description:
    Context

    Resistance to isoniazid (INH) only (monoresistance), with drug susceptibility to rifampin, pyrazinamide, and ethambutol at diagnosis of tuberculosis (TB) disease, can increase the length of treatment.

    Objective

    To describe US trends in INH monoresistance and associated patient characteristics.

    Design

    We performed trend and cross-sectional analyses of US National Tuberculosis Surveillance System surveillance data. We used Joinpoint regression to analyze annual trends in INH monoresistance and logistic regression to identify patient characteristics associated with INH monoresistance.

    Participants

    Culture-positive cases reported to National Tuberculosis Surveillance System during 1993–2016 with drug susceptibility test results to INH, rifampin, pyrazinamide, and ethambutol.

    Main Outcome Measures

    (1) Trends in INH monoresistance; (2) odds ratios for factors associated with INH monoresistance.

    Results

    Isoniazid monoresistance increased significantly from 4.1% of all TB cases in 1993 to 4.9% in 2016. Among US-born patients, INH monoresistance increased significantly from 2003 onward (annual percentage change = 2.8%; 95% confidence interval: 1.4–4.2). During 2003–2016, US-born persons with INH-monoresistant TB were more likely to be younger than 65 years; to be Asian; to be human immunodeficiency virus–infected; or to be a correctional facility resident at the time of diagnosis. Among non–US-born persons, INH resistance did not change significantly during 1993–2016 (annual percentage change = −0.3%; 95% confidence interval: −0.7 to 0.2) and was associated with being aged 15 to 64 years; being Asian, black, or Hispanic; or having a previous history of TB.

    Conclusions

    INH-monoresistant TB has been stable since 1993 among non–US-born persons; it has increased 2.8% annually among US-born persons during 2003–2016. Reasons for this increase should be further investigated.

  • Pubmed ID:
    31688735
  • Pubmed Central ID:
    PMC7190402
  • Document Type:
  • Collection(s):
  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
No Related Documents.
You May Also Like: