Rifampicin Resistance in Tuberculosis Outbreak, London, England

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Jenkins, Claire ; Claxton, Alleyna P. ; Shorten, Robert J. ; McHugh, Timothy D. ; Gillespie, Stephen H.
• Description:
  Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate. Three isolates had a mutation outside the rifampicin resistance-determining region.
• Subjects:
  • Dispatch
  • Keywords: Multi-drug resistant Mycobacterium tuberculosis
  • sequencing
  • rare mutations
  • Antitubercular Agents
  • Base Sequence
  • DNA-Directed RNA Polymerases
  • Disease Outbreaks
  • Drug Resistance, Bacterial
  • Humans
  More +
• Source:
  Emerg Infect Dis. 11(6):931-934.
• Document Type:
  Journal Article
• Volume:
  11
• Issue:
  6
• Download URL:
  https://stacks.cdc.gov/view/cdc/15784/cdc_15784_DS1.pdf
• File Type:
  [PDF - 248.75 KB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:de3e16a58eb789c670ed8a14042b23141dcab76425b550a6679649cfbeea7091