Rifampicin Resistance in Tuberculosis Outbreak, London, England
Published Date:Jun 2005
Source:Emerg Infect Dis. 11(6):931-934.
DNA-Directed RNA Polymerases
Drug Resistance, Bacterial
Keywords: Multi-drug Resistant Mycobacterium Tuberculosis
Molecular Sequence Data
Description:Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate. Three isolates had a mutation outside the rifampicin resistance-determining region.
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