Mycobacterium canettii, the smooth variant of M. tuberculosis, isolated from a Swiss patient exposed in Africa.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pfyffer, G. E. ; Auckenthaler, R. ; van Embden, J. D. ; van Soolingen, D.
• Description:
  An exceptionally smooth and glossy morphotype of Mycobacterium tuberculosis complex was isolated from a 56-year-old Swiss patient with mesenteric tuberculosis. Direct 16S rRNA sequence analysis of the hypervariable signature gene regions revealed a 100% homology to the specific M. tuberculosis complex sequence. Spoligotyping and restriction fragment length polymorphism analyses using the insertion sequences IS6110 and IS1081 and the polymorphic GC-rich sequence as additional genetic markers identified the isolate as the novel taxon M. canettii. Like a Somali child with a similar case, this patient probably contracted the infection in Africa, which raises questions about the geographic distribution of M. canettii.
• Subjects:
  Genetic Variation Humans Male Middle Aged Mycobacterium Mycobacterium Tuberculosis Tuberculosis, Lymph Node
• Source:
  Emerg Infect Dis. 4(4):631-634.
• Document Type:
  Journal Article
• Place as Subject:
  Kenya ; Switzerland ; Uganda
• Volume:
  4
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5b25abe7025017024696e1cbc4f13b09a13d473032c92830638b242a999d5a86
• Download URL:
  https://stacks.cdc.gov/view/cdc/15549/cdc_15549_DS1.pdf
• File Type:
  [PDF - 228.47 KB ]