Role of the exposome in neurodegenerative disease: recent insights and future directions

Details

• Alternative Title:
  Ann Neurol
• Personal Author:
  Sakowski, Stacey A. ; Koubek, Emily J. ; Chen, Kevin S. ; Goutman, Stephen A. ; Feldman, Eva L.
• Description:
  Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024;95:635-652.
• Subjects:
  Alzheimer Disease Exposome Humans Neurodegenerative Diseases Parkinson Disease
• Source:
  Ann Neurol. 95(4):635-652
• Pubmed ID:
  38411261
• Pubmed Central ID:
  PMC11023772
• Document Type:
  Journal Article
• Funding:
  R01TS000327/CC/CDC HHSUnited States/ ; R01 TS000289/TS/ATSDR CDC HHSUnited States/ ; R01 TS000327/TS/ATSDR CDC HHSUnited States/ ; K23 ES027221/ES/NIEHS NIH HHSUnited States/ ; R01 ES030049/ES/NIEHS NIH HHSUnited States/ ; K23ES027221/NH/NIH HHSUnited States/ ; R01TS000289/CC/CDC HHSUnited States/ ; R01 NS127188/NS/NINDS NIH HHSUnited States/ ; R01TS000289/ACL/ACL HHSUnited States/ ; R01NS127188/NH/NIH HHSUnited States/ ; R01ES030049/NH/NIH HHSUnited States/
• Volume:
  95
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:ef6648ccd02c119316ae4cd585dfbd16e4f2f4a87cde40c97375dd4e0174c1db43b5eda7d89c0cbf65113586148f4ef06d9bd7e17bc356c72d52f2f5640ce5b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/154410/cdc_154410_DS1.pdf
• File Type:
  [PDF - 1.04 MB ]