Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Eisenberg, J. N. ; Priest, J. W. ; Lammie, P. J. ; Colford, J. M.
Eisenberg, J. N. ; Priest, J. W. ; Lammie, P. J. ; Colford, J. M. Less -
Description:
Advances in serologic assays for Cryptosporidium parvum have made serology an attractive surveillance tool. The sensitivity, specificity, and predictive value of these new assays for surveillance of immunocompromised populations, however, have not been reported. Using stored serum specimens collected for the San Francisco Men's Health Study, we conducted a case-control study with 11 clinically confirmed cases of cryptosporidiosis. Based on assays using a 27-kDa antigen (CP23), the serum specimens from cases had a median response immunoglobulin (Ig) G level following clinical diagnosis (1,334) and a net response (433, change in IgG level from baseline) that were significantly higher than their respective control values (329 and -32, Wilcoxon p value = 0.01). Receiver operator curves estimated a cutoff of 625 U as the optimal sensitivity (0.86 [0.37, 1.0]) and specificity (0.86 [0.37, 1.0]) for predicting Cryptosporidium infection. These data suggest that the enzyme-linked immunosorbent assay technique can be an effective epidemiologic tool to monitor Cryptosporidium infection in immunocompromised populations.
Subject:
[+]
Adult AIDS-Related Opportunistic Infections Animals Antibodies, Protozoan Case-Control Studies Cryptosporidiosis Cryptosporidium Parvum Humans Male Middle Aged Prospective Studies Research Article
Source:
Emerg Infect Dis. 7(6):1004-1009.
Pubmed ID:
11747729
Pubmed Central ID:
PMC2631897
Document Type:
Journal Article
Funding:
U50/CCU9155546-03/CC/ODCDC CDC HHS/United States
Place as Subject:
San Francisco, CA
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:8e05367189591a1ee5686f3f1e0e32b9dfd3f9accdfff061a5cdd18080c3a985
Download URL:
https://stacks.cdc.gov/view/cdc/15233/cdc_15233_DS1.pdf
File Type:

Supporting Files

• 	11747729.nxml	txt
  	license.txt	txt

More +