Molecular identification of streptomycin monoresistant Mycobacterium tuberculosis related to multidrug-resistant W strain.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bifani, P. ; Mathema, B. ; Campo, M. ; Moghazeh, S. ; Nivin, B. ; Shashkina, E. ; Driscoll, J. ; Munsiff, S. S. ; Frothingham, R. ; Kreiswirth, B. N.
• Description:
  A distinct branch of the Mycobacterium tuberculosis W phylogenetic lineage (W14 group) has been identified and characterized by various genotyping techniques. The W14 group comprises three strain variants: W14, W23, and W26, which accounted for 26 clinical isolates from the New York City metropolitan area. The W14 group shares a unique IS6110 hybridizing banding motif as well as distinct polymorphic GC-rich repetitive sequence and variable number tandem repeat patterns. All W14 group members have high levels of streptomycin resistance. When the streptomycin resistance rpsL target gene was sequenced, all members of this strain family had an identical mutation in codon 43. Patients infected with the W14 group were primarily of non- Hispanic black origin (77%); all were US-born. Including HIV positivity, 84% of the patients had at least one known risk factor for tuberculosis.
• Subjects:
  Adult Antitubercular Agents Bacterial Typing Techniques DNA Transposable Elements Drug Resistance, Bacterial Female Genotype Humans Male Microbial Sensitivity Tests Middle Aged Mycobacterium Tuberculosis Streptomycin Tuberculosis Tuberculosis, Multidrug-Resistant

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• Source:
  Emerg Infect Dis. 7(5):842-848.
• Document Type:
  Journal Article
• Place as Subject:
  New York City, NY
• Volume:
  7
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:314d59e516d8b5f6baef97d2d29663bc2dbc7148152faffc27829d6c4f015e87
• Download URL:
  https://stacks.cdc.gov/view/cdc/15205/cdc_15205_DS1.pdf
• File Type:
  [PDF - 135.46 KB ]