Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Vela Coral, María Claudia ; Fonseca, Nacxiry ; Castañeda, Elizabeth ; Di Fabio, José Luis ; Hollingshead, Susan K. ; Briles, David E.
• Description:
  Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective.
• Subjects:
  Animals Antibodies, Bacterial Antigens, Bacterial Bacterial Proteins Child, Preschool Dna, Bacterial Humans Pneumococcal Infections Pneumococcal Vaccines Polymerase Chain Reaction Rabbits Serotyping Streptococcus Pneumoniae

  More +
• Source:
  Emerg Infect Dis. 7(5):832-836.
• Document Type:
  Journal Article
• Place as Subject:
  Colombia
• Volume:
  7
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:fbc493fda5cdd29f306f7343f83dec59a9f1d5a6bce219211d5c0fe9ee06ff96
• Download URL:
  https://stacks.cdc.gov/view/cdc/15203/cdc_15203_DS1.pdf
• File Type:
  [PDF - 29.12 KB ]