Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells
Published Date:Apr 2005
Source:Emerg Infect Dis. 11(4):629-632.
Cell Line, Tumor
Cytopathogenic Effect, Viral
Human Glioblastoma Cells
Reproducibility Of Results
Reverse Transcriptase Polymerase Chain Reaction
West Nile Fever
West Nile Virus
Description:We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. Changes in expression of 23 genes showed similarities to those in other neurodegenerative diseases. These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus.
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