Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

Beasley, David W.C.; Davis, C. Todd; Estrada-Franco, Jose; Navarro-Lopez, Roberto; Campomanes-Cortes, Arturo; Tesh, Robert B.; Weaver, Scott C.; Barrett, Alan D.T.

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Genome Sequence and Attenuating Mutations in West Nile Virus Isolate from Mexico

Supporting Files Public Domain

Dec 2004
By Beasley, David W.C. ; Davis, C. Todd ; Estrada-Franco, Jose ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Beasley, David W.C. ; Davis, C. Todd ; Estrada-Franco, Jose ; Navarro-Lopez, Roberto ; Campomanes-Cortes, Arturo ; Tesh, Robert B. ; Weaver, Scott C. ; Barrett, Alan D.T.
Description:

The complete genome sequence of a Mexican West Nile virus isolate, TM171-03, included 46 nucleotide (0.42%) and 4 amino acid (0.11%) differences from the NY99 prototype. Mouse virulence differences between plaque-purified variants of TM171-03 with mutations at the E protein glycosylation motif suggest the emergence of an attenuating mutation.
Subjects:

Animals Base Sequence Female Genome, Viral Mice Mutation Virulence
Source:

Emerg Infect Dis. 10(12):2221-2224.
Document Type:

Journal Article
Place as Subject:

Mexico
Location:

North America
Volume:

10
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:11bca75d6dabbe3d377b9c3da7c51e8c6fd7e0591b3e5520fb86bf8cdfcaf7bb
Download URL:

https://stacks.cdc.gov/view/cdc/14696/cdc_14696_DS1.pdf
File Type:

[PDF - 263.82 KB ]

File Language:

English

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