Fatal Spotted Fever Rickettsiosis, Minas Gerais, Brazil

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Galvão, Márcio Antonio Moreira ; Dumler, J. Stephen ; Mafra, Cláudio Lísias ; Calic, Simone Berger ; Chamone, Chequer Buffe ; Filho, Gracco Cesarino ; Olano, Juan Pablo ; Walker, David H.
• Description:
  The emergence and reemergence of a serious infectious disease are often associated with a high case-fatality rate because of misdiagnosis and inappropriate or delayed treatment. The current reemergence of spotted fever rickettsiosis caused by Rickettsia rickettsii in Brazil has resulted in a high proportion of fatal cases. We describe two familial clusters of Brazilian spotted fever in the state of Minas Gerais, involving six children 9 months to 15 years of age; five died. Immunohistochemical investigation of tissues obtained at necropsy of a child in each location, Novo Cruzeiro and Coronel Fabriciano municipalities, established the diagnosis by demonstration of disseminated endothelial infection with spotted fever group rickettsiae. The diagnosis in the two fatal cases from Coronel Fabriciano and the surviving patient from Novo Cruzeiro was further supported by immunofluorescence serologic tests.
• Subjects:
  Adolescent Antibodies, Bacterial Child Child, Preschool Communicable Diseases, Emerging Disease Outbreaks Humans Infant Male Rickettsia Rickettsii Rocky Mountain Spotted Fever

  More +
• Source:
  Emerg Infect Dis. 9(11):1402-1405.
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  9
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:1d5efea047af82c6a1d0684f53dff77157bf6d0aa96e255b9ea3ec92f92ec971
• Download URL:
  https://stacks.cdc.gov/view/cdc/14293/cdc_14293_DS1.pdf
• File Type:
  [PDF - 251.60 KB ]