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Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia
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  1. Pneumocystis jiroveci Dihydropteroate Synthase Genotypes in Immunocompetent Infants and Immunosuppressed Adults, Amiens, France
    Personal Author:
    Totet, Anne; Latouche, Sophie; Lacube, Philippe; Pautard, Jean-Claude; Jounieaux, Vincent; Raccurt, Christian; Roux, Patricia; Nevez, Gilles;
    Published Date:
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    Source:
    Emerg Infect Dis. 10(4):667-673.
    Description:
    To date, investigations of Pneumocystis jirovecii circulation in the human reservoir through the dihydropteroate synthase (DHPS) locus analysis have only been conducted by examining P. jirovecii isolates from immunosuppressed patients with Pneumocyst...
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  2. Genetic variation in Pneumocystis carinii isolates from different geographic regions: implications for transmission.
    Personal Author:
    Beard, C. B.; Carter, J. L.; Keely, S. P.; Huang, L.; Pieniazek, N. J.; Moura, I. N.; Roberts, J. M.; Hightower, A. W.; Bens, M. S.; Freeman, A. R.; Lee, S.; Stringer, J. R.; Duchin, J. S.; del Rio, C.; Rimland, D.; Baughman, R. P.; Levy, D. A.; Dietz, V. J.; Simon, P.; Navin, T. R.;
    Published Date:
    2000 May-Jun
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    Emerg Infect Dis. 6(3):265-272.
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    To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and di...
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  3. Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
    Personal Author:
    Huang, Laurence; Crothers, Kristina; Atzori, Chiara; Benfield, Thomas; Miller, Robert; Rabodonirina, Meja; Helweg-Larsen, Jannik;
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    Oct 2004
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    Emerg Infect Dis. 10(10):1721-1728.
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    Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis. While prophylaxis has reduced the incide...
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  4. Molecular Evidence of Interhuman Transmission of Pneumocystis Pneumonia among Renal Transplant Recipients Hospitalized with HIV-Infected Patients
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    Rabodonirina, Meja; Vanhems, Philippe; Couray-Targe, Sandrine; Gillibert, René-Pierre; Ganne, Christell; Nizard, Nathalie; Colin, Cyrille; Fabry, Jacques; Touraine, Jean-Louis; van Melle, Guy; Nahimana, Aimable; Francioli, Patrick; Hauser, Philippe M.;
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    Oct 2004
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    Emerg Infect Dis. 10(10):1766-1773.
    Description:
    Ten Pneumocystis jirovecii pneumonia (PCP) cases were diagnosed in renal transplant recipients (RTRs) during a 3-year period. Nosocomial transmission from HIV-positive patients with PCP was suspected because these patients shared the same hospital bu...
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  5. Sulfa Use, Dihydropteroate Synthase Mutations, and Pneumocystis jirovecii Pneumonia
    Personal Author:
    Stein, Cheryl R.; Poole, Charles; Kazanjian, Powel; Meshnick, Steven R.;
    Published Date:
    Oct 2004
    Source:
    Emerg Infect Dis. 10(10):1760-1765.
    Description:
    A systematic review was conducted to examine the associations in Pneumocystis jirovecii pneumonia (PCP) patients between dihydropteroate synthase (DHPS) mutations and sulfa or sulfone (sulfa) prophylaxis and between DHPS mutations and sulfa treatment...
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