Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia

Nahimana, Aimable; Rabodonirina, Meja; Helweg-Larsen, Jannik; Meneau, Isabelle; Francioli, Patrick; Bille, Jacques; Hauser, Philippe M.

doi:10.3201/eid0907.030249

i

Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia

Supporting Files Public Domain

Jul 2003
By Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik
http://dx.doi.org/10.3201/eid0907.030249

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik ; Meneau, Isabelle ; Francioli, Patrick ; Bille, Jacques ; Hauser, Philippe M.
Description:

Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Subjects:
Source:

Emerg Infect Dis. 9(7):864-867.
Document Type:

Journal Article
Volume:

9
Issue:

7
Download URL:

https://stacks.cdc.gov/view/cdc/14182/cdc_14182_DS1.pdf
File Type:

[PDF - 528.62 KB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9bd64fdb6e4d22058b8daa084d830528afe2c61c5efaebe5923b3d169b84c8c8

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