Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid0907.030249
Personal Author:
Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik ; Meneau, Isabelle ; Francioli, Patrick ; ... More +
Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik ; Meneau, Isabelle ; Francioli, Patrick ; Bille, Jacques ; Hauser, Philippe M. ; Less -
Description:
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Subject:
[+]
Adult
AIDS
Anti-Infective Agents
Dihydropteroate Synthase
Dispatch
DNA, Fungal
Drug Pressure
Drug Resistance
Drug Resistance, Fungal
Female
Fungal Typing
Genotype
Humans
Male
Middle Aged
Mutation
Pneumocystis
Pneumocystis Carinii
Pneumonia
Pneumonia, Pneumocystis
Recurrence
Sulfonamides
Sulfones
Dihydropteroate Synthase

Source:
Emerg Infect Dis. 9(7):864-867. ;
Document Type:
Journal Article ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:9bd64fdb6e4d22058b8daa084d830528afe2c61c5efaebe5923b3d169b84c8c8
File Type:

Supporting Files

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