Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia

Nahimana, Aimable; Rabodonirina, Meja; Helweg-Larsen, Jannik; Meneau, Isabelle; Francioli, Patrick; Bille, Jacques; Hauser, Philippe M.

doi:10.3201/eid0907.030249

i

Sulfa Resistance and Dihydropteroate Synthase Mutants in Recurrent Pneumocystis carinii Pneumonia

Supporting Files Public Domain

Jul 2003
By Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Nahimana, Aimable ; Rabodonirina, Meja ; Helweg-Larsen, Jannik ; Meneau, Isabelle ; Francioli, Patrick ; Bille, Jacques ; Hauser, Philippe M.
Description:

Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Subjects:

Adult AIDS Anti-Infective Agents Dihydropteroate Synthase Dispatch DNA, Fungal Drug Pressure Drug Resistance Drug Resistance, Fungal Female Fungal Typing Genotype Humans Male Middle Aged Mutation Pneumocystis Pneumocystis Carinii Pneumonia Pneumonia, Pneumocystis Recurrence Sulfonamides Sulfones
Source:

Emerg Infect Dis. 9(7):864-867.
Document Type:

Journal Article
Volume:

9
Issue:

7
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9bd64fdb6e4d22058b8daa084d830528afe2c61c5efaebe5923b3d169b84c8c8
Download URL:

https://stacks.cdc.gov/view/cdc/14182/cdc_14182_DS1.pdf
File Type:

[PDF - 528.62 KB ]

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