Respiratory and Urinary Tract Infections, Arthritis, and Asthma Associated with HTLV-I and HTLV-II Infection

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Murphy, Edward L. ; Wang, Baoguang ; Sacher, Ronald A. ; Fridey, Joy ; Smith, James W. ; Nass, Catharie C. ; Newman, Bruce ; Ownby, Helen E. ; Garratty, George ; Hutching, Sheila T. ; Schreiber, George B.
• Description:
  Human T-lymphotropic virus types I and II (HTLV-I and -II) cause myelopathy; HTLV-I, but not HTLV-II, causes adult T-cell leukemia. Whether HTLV-II is associated with other diseases is unknown. Using survival analysis, we studied medical history data from a prospective cohort of HTLV-I- and HTLV-II-infected and -uninfected blood donors, all HIV seronegative. A total of 152 HTLV-I, 387 HTLV-II, and 799 uninfected donors were enrolled and followed for a median of 4.4, 4.3, and 4.4 years, respectively. HTLV-II participants had significantly increased incidences of acute bronchitis (incidence ratio [IR] = 1.68), bladder or kidney infection (IR = 1.55), arthritis (IR = 2.66), and asthma (IR = 3.28), and a borderline increase in pneumonia (IR = 1.82, 95% confidence interval [CI] 0.98 to 3.38). HTLV-I participants had significantly increased incidences of bladder or kidney infection (IR = 1.82), and arthritis (IR = 2.84). We conclude that HTLV-II infection may inhibit immunologic responses to respiratory infections and that both HTLV-I and -II may induce inflammatory or autoimmune reactions.
• Subjects:
  Adult Arthritis Asthma Blood Donors Female Hiv Seronegativity Htlv-Ii Infections Htlv-I Infections Humans Incidence Male Middle Aged Prospective Studies Respiratory Tract Infections Survival Analysis Urinary Tract Infections

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• Source:
  Emerg Infect Dis. 10(1):109-116.
• Document Type:
  Journal Article
• Funding:
  N01-HB-47114/HB/NHLBI NIH HHS/United States ; N01-HB-97078/HB/NHLBI NIH HHS/United States ; N01-HB-97079/HB/NHLBI NIH HHS/United States ; N01-HB-97080/HB/NHLBI NIH HHS/United States ; N01-HB-97081/HB/NHLBI NIH HHS/United States ; N01-HB-97082/HB/NHLBI NIH HHS/United States ; R01-HL-62235/HL/NHLBI NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  10
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:87f1cc90293c8886914a45774d27bb8269a103b227f5cf44d465bac52cdbf552
• Download URL:
  https://stacks.cdc.gov/view/cdc/14166/cdc_14166_DS1.pdf
• File Type:
  [PDF - 134.61 KB ]