Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Munsiff, Sonal S. ; Bassoff, Trina ; Nivin, Beth ; Li, Jiehui ; Sharma, Anu ; ... More +
Munsiff, Sonal S. ; Bassoff, Trina ; Nivin, Beth ; Li, Jiehui ; Sharma, Anu ; Bifani, Pablo ; Mathema, Barun ; Driscoll, Jeffrey ; Kreiswirth, Barry N. ; Less -
Description:
From January 1, 1995, to December 31, 1997, we reviewed records of all New York City patients who had multidrug-resistant tuberculosis (MDRTB); we performed insertion sequence (IS) 6110-based DNA genotyping on the isolates. Secondary genotyping was performed for low IS6110 copy band strains. Patients with identical DNA pattern strains were considered clustered. From 1995 through 1997, MDRTB was diagnosed in 241 patients; 217 (90%) had no prior treatment history, and 166 (68.9%) were born in the United States or Puerto Rico. Compared with non-MDRTB patients, MDRTB patients were more likely to be born in the United States, have HIV infection, and work in health care. Genotyping results were available for 234 patients; 153 (65.4%) were clustered, 126 (82.3%) of them in eight clusters of >or=4 patients. Epidemiologic links were identified for 30 (12.8%) patients; most had been exposed to patients diagnosed before the study period. These strains were likely transmitted in the early 1990 s when MDRTB outbreaks and tuberculosis transmission were widespread in New York.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
Antitubercular Agents
Child
Child, Preschool
Cluster Analysis
Drug Resistance, Multiple, Bacterial
Female
Genotype
Humans
Male
Middle Aged
Molecular Epidemiology
Mycobacterium Tuberculosis
Risk Factors
Time Factors
Tuberculosis

Source:
Emerg Infect Dis. 8(11):1230-1238. ;
Document Type:
Journal Article ;
Place as Subject:
New York City, NY ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:12dee84524c32cd5f6688860c25b9538fcbd33495a61b13a85a8900db688aae8
File Type:

Supporting Files

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  	02-0288_FinalR.nxml	txt
  	license.txt	txt

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