Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Stratton, Charles W.
Description:
The global emergence of antibacterial resistance among common and atypical respiratory pathogens in the last decade necessitates the strategic application of antibacterial agents. The use of bactericidal rather than bacteriostatic agents as first-line therapy is recommended because the eradication of microorganisms serves to curtail, although not avoid, the development of bacterial resistance. Bactericidal activity is achieved with specific classes of antimicrobial agents as well as by combination therapy. Newer classes of antibacterial agents, such as the fluoroquinolones and certain members of the macrolide/lincosamine/streptogramin class have increased bactericidal activity compared with traditional agents. More recently, the ketolides (novel, semisynthetic, erythromycin-A derivatives) have demonstrated potent bactericidal activity against key respiratory pathogens, including Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, and Moraxella catarrhalis. Moreover, the ketolides are associated with a low potential for inducing resistance, making them promising first-line agents for respiratory tract infections.
Subjects:
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Anti-Bacterial Agents Drug Resistance, Bacterial Drug Resistance, Microbial Drug Therapy, Combination Gram-Negative Bacteria Gram-Negative Bacterial Infections Humans Ketolide Ketolides Macrolides Pathogenicity Perspective Pneumonia, Pneumococcal Respiratory Tract Infections Streptococcus Pneumoniae Therapeutic Use
Source:
Emerg Infect Dis. 9(1):10-16.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:2ab09bf00d0ba6c1490472aa2e0c9a87013b0c84a4d3481e03a2793f62d080e3
Download URL:
https://stacks.cdc.gov/view/cdc/13974/cdc_13974_DS1.pdf
File Type:

Supporting Files

• 	02-0172.nxml	txt
  	license.txt	txt

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