Genetic and Antigenic Analysis of the First A/New Caledonia/20/99-like H1N1 Influenza Isolates Reported in the Americas

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Daum, Luke T. ; Canas, Linda C. ; Smith, Catherine B. ; Klimov, Alexander ; Huff, William ; Barnes, William ; Lohman, Kenton L.
• Description:
  From February through May of 1999, 13 cases of Influenza A virus (FLUAV), type H1N1 were reported at a Department of Defense influenza surveillance sentinel site in Lima, Peru. Genetic and antigenic analysis by hemagglutination inhibition and direct nucleotide sequencing of the HA1 region of the hemagglutinin gene were performed on two isolates, A/Peru/1641/99 and A/Peru/1798/99. Both isolates were distinct from the Bayern/7/95-like viruses circulating in the Americas and closely related to a Beijing/262/95-like variant, A/New Caledonia/20/99. With the exception of travel-related cases, the detection of these isolates represents the first appearance of New Caledonia/20/99-like viruses in the Americas. Since the characterization of these Peru isolates, a number of New Caledonia/20/99-like viruses have been reported worldwide. For the 2000/01 and 2001/02 influenza seasons, the World Health Organization (WHO) has recommended the inclusion of A/New Caledonia/20/99 as the H1N1 vaccine component for both the southern and northern hemispheres.
• Subjects:
  Amino Acid Sequence Animals Antigens, Viral Ferrets Humans Influenza, Human Influenzavirus A Molecular Sequence Data Mutation Phylogeny Prevalence Sentinel Surveillance

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• Source:
  Emerg Infect Dis. 8(4):408-412.
• Document Type:
  Journal Article
• Place as Subject:
  Peru
• Volume:
  8
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d12a8644d905027dbdf1efd1a52942a3d51a764622183325157855c9187e121f
• Download URL:
  https://stacks.cdc.gov/view/cdc/13826/cdc_13826_DS1.pdf
• File Type:
  [PDF - 271.05 KB ]