Animal Models and Mechanisms of Tobacco Smoke-induced Chronic Obstructive Pulmonary Disease (COPD)

Details

• Alternative Title:
  J Toxicol Environ Health B Crit Rev
• Personal Author:
  Upadhyay, Priya ; Wu, Ching-Wen ; Pham, Alexa ; Zeki, Amir A. ; Royer, Christopher M. ; Kodavanti, Urmila P. ; Takeuchi, Minoru ; Bayram, Hasan ; Pinkerton, Kent E.
• Description:
  Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized by emphysema, mucus hypersecretion, and persistent lung inflammation, and clinically by chronic airflow obstruction and symptoms of dyspnea, cough, and fatigue in patients. A cluster of pathologies including chronic bronchitis, emphysema, asthma, and cardiovascular disease in the form of hypertension and atherosclerosis variably coexist in COPD patients. Underlying causes for COPD include primarily tobacco use but may also be driven by exposure to air pollutants, biomass burning, and workplace related fumes and chemicals. While no single animal model might mimic all features of human COPD, a wide variety of published models have collectively helped to improve our understanding of disease processes involved in the genesis and persistence of COPD. In this review, the pathogenesis and associated risk factors of COPD are examined in different mammalian models of the disease. Each animal model included in this review is exclusively created by tobacco smoke (TS) exposure. As animal models continue to aid in defining the pathobiological mechanisms of and possible novel therapeutic interventions for COPD, the advantages and disadvantages of each animal model are discussed.
• Subjects:
  Animals Disease Models, Animal Emphysema Humans Mammals Pulmonary Disease, Chronic Obstructive Pulmonary Emphysema Smoke Tobacco Smoke Pollution
• Keywords:
  Animal Models Chronic Bronchitis Chronic Obstructive Pulmonary Disease (COPD) Emphysema Tobacco Smoke
• Source:
  J Toxicol Environ Health B Crit Rev. 26(5):275-305
• Pubmed ID:
  37183431
• Pubmed Central ID:
  PMC10718174
• Document Type:
  Journal Article
• Funding:
  R03 AI139648/AI/NIAID NIH HHSUnited States/ ; P51 OD011107/OD/NIH HHSUnited States/ ; P30 ES005707/ES/NIEHS NIH HHSUnited States/ ; P51 RR000169/RR/NCRR NIH HHSUnited States/ ; P30 ES023513/ES/NIEHS NIH HHSUnited States/ ; U54 OH007550/OH/NIOSH CDC HHSUnited States/ ; K01 OD024782/OD/NIH HHSUnited States/ ; R01 ES011634/ES/NIEHS NIH HHSUnited States/ ; R03 HL148486/HL/NHLBI NIH HHSUnited States/ ; U01 ES027288/ES/NIEHS NIH HHSUnited States/
• Volume:
  26
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:747e804385916873e761f67a74de22952f0f5cbca30cbc75e41c836e0514ff9b
• Download URL:
  https://stacks.cdc.gov/view/cdc/137177/cdc_137177_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]