Animal Models and Mechanisms of Tobacco Smoke-Induced Chronic Obstructive Pulmonary Disease (COPD)

Details

• Personal Author:
  Bayram H ; Kodavanti UP ; Pham A ; Pinkerton KE ; Royer CM ; Takeuchi M ; Upadhyay P ; Wu C-W ; Zeki AA
• Description:
  Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and its global health burden is increasing. COPD is characterized by emphysema, mucus hypersecretion, and persistent lung inflammation, and clinically by chronic airflow obstruction and symptoms of dyspnea, cough, and fatigue in patients. A cluster of pathologies including chronic bronchitis, emphysema, asthma, and cardiovascular disease in the form of hypertension and atherosclerosis variably coexist in COPD patients. Underlying causes for COPD include primarily tobacco use but may also be driven by exposure to air pollutants, biomass burning, and workplace related fumes and chemicals. While no single animal model might mimic all features of human COPD, a wide variety of published models have collectively helped to improve our understanding of disease processes involved in the genesis and persistence of COPD. In this review, the pathogenesis and associated risk factors of COPD are examined in different mammalian models of the disease. Each animal model included in this review is exclusively created by tobacco smoke (TS) exposure. As animal models continue to aid in defining the pathobiological mechanisms of and possible novel therapeutic interventions for COPD, the advantages and disadvantages of each animal model are discussed. [Description provided by NIOSH]
• Subjects:
  Animals Occupational Health Respiratory System Respiratory Tract Diseases Safety Smoke Tobacco Products
• Keywords:
  Animal Models Animal Studies Author Keywords: Chronic Obstructive Pulmonary Disease Chronic Bronchitis Chronic Obstructive Pulmonary Disease COPD Emphysema Pathogenesis Respiratory Diseases Tobacco Smoke
• ISSN:
  1093-7404
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; North Carolina ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  275-305
• Volume:
  26
• Issue:
  5
• NIOSHTIC Number:
  nn:20068176
• Citation:
  J Toxicol Environ Health B 2023 Jul; 26(5):275-305
• Contact Point Address:
  Kent E. Pinkerton, Center for Health and the Environment, University of California, Davis, CA 95616, USA
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part B: Critical Reviews
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:afd83b018236b9a19e28bb143d13953d56330b8da32a7450523990cb5067e36c254147d7c23e2c734d81a753c46f423aff5106a537bdd5125146b345d7eb6301
• Download URL:
  https://stacks.cdc.gov/view/cdc/230386/cdc_230386_DS1.pdf
• File Type:
  [PDF - 4.99 MB ]