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Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
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11 2023
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Source: Emerg Infect Dis. 2023; 29(11):2398-2400
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Alternative Title:Emerg Infect Dis
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Description:We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla|, leading to bla| overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.
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Pubmed ID:37877674
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Pubmed Central ID:PMC10617341
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