Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Cui, Qiaozhen ; Wang, Chen ; Wang, Qichen ; Qin, Juanxiu ; Li, Min ; Ding, Baixing ; Shen, Zhen
• Description:
  We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for bla|, leading to bla| overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.
• Subjects:
  Anti-Bacterial Agents Bacterial Proteins Beta-Lactamases Carbapenem-Resistant Enterobacteriaceae Ceftazidime Humans Klebsiella Infections Klebsiella Pneumoniae Microbial Sensitivity Tests
• Source:
  Emerg Infect Dis. 2023; 29(11):2398-2400
• Pubmed ID:
  37877674
• Pubmed Central ID:
  PMC10617341
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:518d060d67dff710270a0f12cb86810cbc182cc2a9b9c2b00ec2cd0074a2d2fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/135976/cdc_135976_DS1.pdf
• File Type:
  [PDF - 778.86 KB ]