Genomic Epidemiology of Global Carbapenemase-Producing Escherichia coli, 2015–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Peirano, Gisele ; Chen, Liang ; Nobrega, Diego ; Finn, Thomas J. ; Kreiswirth, Barry N. ; DeVinney, Rebekah ; Pitout, Johann D.D.
• Description:
  We describe the global molecular epidemiology of 229 carbapenemase-producing Escherichia coli in 36 countries during 2015-2017. Common carbapenemases were oxacillinase (OXA) 181 (23%), New Delhi metallo-β-lactamase (NDM) 5 (20%), OXA-48 (17%), Klebsiella pneumoniae carbapenemase 2 (15%), and NDM-1 (10%). We identified 5 dominant sequence types (STs); 4 were global (ST410, ST131, ST167, and ST405), and 1 (ST1284) was limited to Turkey. OXA-181 was frequent in Jordan (because of the ST410-B4/H24RxC subclade) and Turkey (because of ST1284). We found nearly identical IncX3-bla| plasmids among 11 STs from 12 countries. NDM-5 was frequent in Egypt, Thailand (linked with ST410-B4/H24RxC and ST167-B subclades), and Vietnam (because of ST448). OXA-48 was common in Turkey (linked with ST11260). Global K. pneumoniae carbapenemases were linked with ST131 C1/H30 subclade and NDM-1 with various STs. The global carbapenemase E. coli population is dominated by diverse STs with different characteristics and varied geographic distributions, requiring ongoing genomic surveillance.
• Subjects:
  Anti-Bacterial Agents Bacterial Proteins Beta-Lactamases Carbapenem-Resistant Enterobacteriaceae Escherichia Coli Infections Humans Klebsiella Pneumoniae Microbial Sensitivity Tests
• Source:
  Emerg Infect Dis. 2022; 28(5):924-931
• Pubmed ID:
  35451367
• Pubmed Central ID:
  PMC9045447
• Document Type:
  Journal Article
• Funding:
  10016015/CIHRCanada/
• Volume:
  28
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:23d1fdb072525d80db04345394b1f0ca702733e47c9225b13d14f4413c5de81b
• Download URL:
  https://stacks.cdc.gov/view/cdc/117300/cdc_117300_DS1.pdf
• File Type:
  [PDF - 549.70 KB ]