Posttransfusion Sepsis Attributable to Bacterial Contamination in Platelet Collection Set Manufacturing Facility, United States

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Kracalik, Ian ; Kent, Alyssa G. ; Villa, Carlos H. ; Gable, Paige ; Annambhotla, Pallavi ; McAllister, Gillian ; Yokoe, Deborah ; Langelier, Charles R. ; Oakeson, Kelly ; Noble-Wang, Judith ; Illoh, Orieji ; Halpin, Alison Laufer ; Eder, Anne F. ; Basavaraju, Sridhar V.
• Description:
  During May 2018‒December 2022, we reviewed transfusion-transmitted sepsis cases in the United States attributable to polymicrobial contaminated apheresis platelet components, including Acinetobacter calcoaceticus‒baumannii complex or Staphylococcus saprophyticus isolated from patients and components. Transfused platelet components underwent bacterial risk control strategies (primary culture, pathogen reduction or primary culture, and secondary rapid test) before transfusion. Environmental samples were collected from a platelet collection set manufacturing facility. Seven sepsis cases from 6 platelet donations from 6 different donors were identified in patients from 6 states; 3 patients died. Cultures identified Acinetobacter calcoaceticus‒baumannii complex in 6 patients and 6 transfused platelets, S. saprophyticus in 4 patients and 4 transfused platelets. Whole-genome sequencing showed environmental isolates from the manufacturer were closely related genetically to patient and platelet isolates, indicating the manufacturer was the most probable source of recurrent polymicrobial contamination. Clinicians should maintain awareness of possible transfusion-transmitted sepsis even when using bacterial risk control strategies.
• Subjects:
  Expedited Posttransfusion Sepsis Attributable To Bacterial Contamination In Platelet Collection Set Manufacturing Facility, United States Research
• Keywords:
  Acinetobacter Calcoaceticus‒baumannii Complex Bacteria Bacterial Contamination Blood Platelets Blood Safety Blood Transfusion Blood Transfusions Humans Manufacturing Facility Platelet Collection Set Platelets Platelet Transfusion Posttransfusion Sepsis Sepsis Staphylococcus Saprophyticus United States

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• Source:
  Emerg Infect Dis. 2023; 29(10):1979-1989
• Pubmed ID:
  37561399
• Pubmed Central ID:
  PMC10521617
• Document Type:
  Journal Article
• Volume:
  29
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:48fc3f81f48a9768969e97021b218841f1ec61ee18733b6b7dc2177d834b9af7
• Download URL:
  https://stacks.cdc.gov/view/cdc/134754/cdc_134754_DS1.pdf
• File Type:
  [PDF - 3.44 MB ]