Cancer risk among HIV-exposed uninfected children in the United States

Details

• Alternative Title:
  AIDS
• Personal Author:
  Horner, Marie-Josèphe ; Hazra, Rohan ; Barnholtz-Sloan, Jill S. ; Shiels, Meredith S. ; Engels, Eric A.
• Description:
  In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero , who remained HIV-uninfected after birth (1990-2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8-4.8, P  = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.
• Subjects:
  Anti-HIV Agents Child Female HIV Infections Humans Infant Neoplasms Pregnancy Pregnancy Complications, Infectious Prenatal Exposure Delayed Effects Prospective Studies

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• Source:
  AIDS. 37(3):549-551
• Pubmed ID:
  36544264
• Pubmed Central ID:
  PMC9877176
• Document Type:
  Journal Article
• Funding:
  U62 PS004011/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201300019C/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; Z99 CA999999/ImNIH/Intramural NIH HHSUnited States/ ; U62 PS001005/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201800007C/CA/NCI NIH HHSUnited States/ ; HHSN261201300019I/CA/NCI NIH HHSUnited States/
• Place as Subject:
  United States
• Volume:
  37
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:27cc86cd4c6236d30e97452dacc701c8a0dbfffae5f93ceffa2bd58f43e55bc8
• Download URL:
  https://stacks.cdc.gov/view/cdc/124064/cdc_124064_DS1.pdf
• File Type:
  [PDF - 50.02 KB ]