Cancer risk among HIV-exposed uninfected children in the United States

Horner, Marie-Josèphe; Hazra, Rohan; Barnholtz-Sloan, Jill S.; Shiels, Meredith S.; Engels, Eric A.

doi:10.1097/QAD.0000000000003458

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Cancer risk among HIV-exposed uninfected children in the United States

3 01 2023
By Horner, Marie-Josèphe ; Hazra, Rohan ; Barnholtz-Sloan, Jill S. ; ...
http://dx.doi.org/10.1097/QAD.0000000000003458
Source: AIDS. 37(3):549-551

[PDF-50.02 KB]

English

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Details:

Alternative Title:

AIDS
Personal Author:

Horner, Marie-Josèphe ; Hazra, Rohan ; Barnholtz-Sloan, Jill S. ; Shiels, Meredith S. ; Engels, Eric A.

Horner, Marie-Josèphe ; Hazra, Rohan ; Barnholtz-Sloan, Jill S. ; Shiels, Meredith S. ; Engels, Eric A. Less -
Description:

In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero , who remained HIV-uninfected after birth (1990-2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8-4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.
Subjects:

[+]

Anti-HIV Agents Child Female HIV Infections Humans Infant Neoplasms Pregnancy Pregnancy Complications, Infectious Prenatal Exposure Delayed Effects Prospective Studies
Source:

AIDS. 37(3):549-551
Pubmed ID:

36544264
Pubmed Central ID:

PMC9877176
Document Type:

Journal Article
Funding:

U62 PS004011/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201300019C/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; Z99 CA999999/ImNIH/Intramural NIH HHSUnited States/ ; U62 PS001005/PS/NCHHSTP CDC HHSUnited States/ ; ... More +

U62 PS004011/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201300019C/CA/NCI NIH HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; Z99 CA999999/ImNIH/Intramural NIH HHSUnited States/ ; U62 PS001005/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201800007C/CA/NCI NIH HHSUnited States/ ; HHSN261201300019I/CA/NCI NIH HHSUnited States/ Less -
Place as Subject:

United States
Volume:

37
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:27cc86cd4c6236d30e97452dacc701c8a0dbfffae5f93ceffa2bd58f43e55bc8
Download URL:

https://stacks.cdc.gov/view/cdc/124064/cdc_124064_DS1.pdf
File Type:

	nihms-1855920.nxml	xml
	NIHMS1855920-supplement-Supplemental_Materials.docx	docx

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