Challenges, risks, and opportunities of antiretroviral drugs in women of reproductive potential

Details

• Alternative Title:
  Expert Rev Anti Infect Ther
• Personal Author:
  Henderson, Alexis C. ; Cholli, Preetam ; Lampe, Margaret A. ; Kourtis, Athena P.
• Description:
  Introduction:
  
  The HIV/AIDS epidemic has been one of the greatest challenges in global health, significantly affecting women of reproductive potential. Considerable advances in antiretroviral therapy for women living with HIV have contributed to improvements in quality of life, better reproductive and birth outcomes, and a reduced risk of perinatal transmission.
  
  Areas covered:
  
  Despite the progress made, persistent challenges in access and adherence to antiretroviral drugs may limit their benefits for some women. More pharmacokinetic and safety studies in pregnant and lactating women are urgently needed, as are prospective surveillance systems to evaluate associations between fetal and infant antiretroviral exposures, drug–drug interactions, and pregnancy outcomes.
  
  Expert opinion:
  
  Multipurpose technologies, such as combined HIV and other STI or unintended pregnancy prevention, and innovative delivery methods, such as the development of long-acting antiretrovirals, have the potential to reduce adherence challenges and enhance quality of life for women with HIV. Parallel advances in drug safety testing and surveillance are needed to ensure the health and safety of women with or at risk for HIV and children at risk for perinatal transmission.
  
  
• Subjects:
  Anti-HIV Agents Child Female HIV Infections Humans Infant Infectious Disease Transmission, Vertical Lactation Pharmaceutical Preparations Pregnancy Pregnancy Complications, Infectious Prospective Studies Quality Of Life

  More +
• Keywords:
  Antiretroviral Breastfeeding HIV Infant Feeding Pregnancy Reproductive Age Women
• Source:
  Expert Rev Anti Infect Ther. 22(4):153-167
• Pubmed ID:
  38517686
• Pubmed Central ID:
  PMC11287786
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  22
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:129d5d720dbb58b8b89115ff570f465ab46f059b9824267043f2ccf49488653274597d792f5dea93ebdbadb572e48f36131999c52f432c52c6b07ecc0c1c37cd
• Download URL:
  https://stacks.cdc.gov/view/cdc/159484/cdc_159484_DS1.pdf
• File Type:
  [PDF - 389.40 KB ]