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Outbreak of IncX8 Plasmid–Mediated KPC-3–Producing Enterobacterales Infection, China
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7 2022
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Source: Emerg Infect Dis. 2022; 28(7):1421-1430
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Alternative Title:Emerg Infect Dis
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Description:Carbapenem-resistant Enterobacterales (CRE) infection is highly endemic in China; Klebsiella pneumoniae carbapenemase (KPC) 2-producing CRE is the most common, whereas KPC-3-producing CRE is rare. We report an outbreak of KPC-3-producing Enterobacterales infection in China. During August 2020-June 2021, 25 bla|-positive Enterobacteriale isolates were detected from 24 patients in China. Whole-genome sequencing analysis revealed that the bla| genes were harbored by IncX8 plasmids. The outbreak involved clonal expansion of KPC-3-producing Serratia marcescens and transmission of bla| plasmids across different species. The bla| plasmids demonstrated high conjugation frequencies (10| to 10|). A Galleria mellonella infection model showed that 2 sequence type 65 K2 K. pneumoniae strains containing bla| plasmids were highly virulent. A ceftazidime/avibactam in vitro selection assay indicated that the KPC-3-producing strains can readily develop resistance. The spread of bla|-harboring IncX8 plasmids and these KPC-3 strains should be closely monitored in China and globally.
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Pubmed ID:35731165
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Pubmed Central ID:PMC9239885
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