Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Annand, Edward J. ; Horsburgh, Bethany A. ; Xu, Kai ; Reid, Peter A. ; Poole, Ben ; de Kantzow, Maximillian C. ; Brown, Nicole ; Tweedie, Alison ; Michie, Michelle ; Grewar, John D. ; Jackson, Anne E. ; Singanallur, Nagendrakumar B. ; Plain, Karren M. ; Kim, Karan ; Tachedjian, Mary ; van der Heide, Brenda ; Crameri, Sandra ; Williams, David T. ; Secombe, Cristy ; Laing, Eric D. ; Sterling, Spencer ; Yan, Lianying ; Jackson, Louise ; Jones, Cheryl ; Plowright, Raina K. ; Peel, Alison J. ; Breed, Andrew C. ; Diallo, Ibrahim ; Dhand, Navneet K. ; Britton, Philip N. ; Broder, Christopher C. ; Smith, Ina ; Eden, John-Sebastian
  More +
• Description:
  We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing from a horse in Queensland, Australia, that died from acute illness with signs consistent with HeV infection. Using whole-genome sequencing and phylogenetic analysis, we determined the variant had ≈83% nt identity with prototypic HeV. In silico and in vitro comparisons of the receptor-binding protein with prototypic HeV support that the human monoclonal antibody m102.4 used for postexposure prophylaxis and current equine vaccine will be effective against this variant. An updated quantitative PCR developed for routine surveillance resulted in subsequent case detection. Genetic sequence consistency with virus detected in grey-headed flying foxes suggests the variant circulates at least among this species. Studies are needed to determine infection kinetics, pathogenicity, reservoir-species associations, viral-host coevolution, and spillover dynamics for this virus. Surveillance and biosecurity practices should be updated to acknowledge HeV spillover risk across all regions frequented by flying foxes.
• Subjects:
  • Research
  • Novel Hendra Virus Variant Detected By Sentinel Surveillance Of Horses In Australia
  • Hendra Virus
  • Zoonoses
  • Viruses
  • Hendra Henipavirus
  • Viral Encephalitis
  • Meningitis/Encephalitis
  • Vasculitis
  • Central Nervous System
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• Source:
  Emerg Infect Dis. 2022; 28(3):693-704
• Pubmed ID:
  35202527
• Pubmed Central ID:
  PMC8888208
• Document Type:
  Journal Article
• Funding:
  U19 AI142764/AI/NIAID NIH HHSUnited States/
• Volume:
  28
• Issue:
  3
• Download URL:
  https://stacks.cdc.gov/view/cdc/115205/cdc_115205_DS1.pdf
• File Type:
  [PDF - 5.02 MB]
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:98dd606323f829c50ca1106e2c796f80ec87cbeaf04cce87f46eb4d4a2c70311