Parental occupation and risk of childhood retinoblastoma in Denmark

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Omidakhsh, Negar ; Hansen, Johnni ; Ritz, Beate ; Coleman, Anne L. ; McKean-Cowdin, Roberta ; Olsen, Jorn ; Heck, Julia E.
• Description:
  Objective:
  
  Retinoblastoma is the most common primary intraocular tumor affecting children. We examine the role of parental occupational exposures and risk of retinoblastoma among offspring.
  
  Methods:
  
  Our population-based case-control study linked data from four nationwide Danish registries and included all cases of retinoblastoma diagnosed in Danish children (<5 years, n=144) between 1975–2014. We focused on two biologically relevant time periods: 90 days preconception to conception for fathers; conception to birth for mothers. Parents were grouped into major industry headings created from Danish industry codes.
  
  Results:
  
  We observed increased risk of all retinoblastoma for children of fathers in the food and drink industry and iron and metal industry. Bilateral disease was associated with paternal work in manufacturing and land transportation.
  
  Conclusion:
  
  Our results suggest that some occupational exposures may increase the risk of childhood sporadic retinoblastoma.
  
  
• Subjects:
  Article Childhood Cancer Occupational Exposures Parental Exposures Retinoblastoma
• Source:
  J Occup Environ Med. 63(3):256-261
• Pubmed ID:
  33395168
• Pubmed Central ID:
  PMC8259454
• Document Type:
  Journal Article
• Funding:
  R21 CA175959/CA/NCI NIH HHSUnited States/ ; R03 ES021643/ES/NIEHS NIH HHSUnited States/ ; T42 OH008412/OH/NIOSH CDC HHSUnited States/ ; T42OH008412/ACL/ACL HHSUnited States/ ; R21 ES019986/ES/NIEHS NIH HHSUnited States/
• Volume:
  63
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:689a2faf4dcf5a2b070d0acd37e2caf383208a2ddd34e253d5d9dff4e66bcaac
• Download URL:
  https://stacks.cdc.gov/view/cdc/107725/cdc_107725_DS1.pdf
• File Type:
  [PDF - 87.81 KB ]