Parental Occupation and Risk of Childhood Retinoblastoma in Denmark

Details

• Personal Author:
  Coleman AL ; Hansen J ; Heck JE ; McKean-Cowdin R ; Olsen J ; Omidakhsh N ; Ritz B
• Description:
  Objective: Retinoblastoma is the most common primary intraocular tumor affecting children. We examine the role of parental occupational exposures and risk of retinoblastoma among offspring. Methods: Our population-based case-control study linked data from four nationwide Danish registries and included all cases of retinoblastoma diagnosed in Danish children (<5 y, n = 144) between 1975 and 2014. We focused on two biologically relevant time periods: 90 days preconception to conception for fathers; conception to birth for mothers. Parents were grouped into major industry headings created from Danish industry codes. Results: We observed increased risk of all retinoblastoma for children of fathers in the food and drink industry and iron and metal industry. Bilateral disease was associated with paternal work in manufacturing and land transportation. Conclusion: Our results suggest that some occupational exposures may increase the risk of childhood sporadic retinoblastoma. [Description provided by NIOSH]
• Subjects:
  Epidemiology Eye Neoplasms Occupational Exposure Occupational Health Pregnancy Safety Sense Organs
• Keywords:
  Author Keywords: Retinoblastoma Cancer Rates Childhood Cancer Children Eyes Occupational Exposure Occupational Exposures Occupations Parental Exposures Population Based Studies Prenatal Exposure Tumors

  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  256-261
• Volume:
  63
• Issue:
  3
• NIOSHTIC Number:
  nn:20061768
• Citation:
  J Occup Environ Med 2021 Mar; 63(3):256-261
• Contact Point Address:
  Negar Omidakhsh, PhD, Southern California NIOSH Education and Research Center, University of California Los Angeles, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772
• Email:
  nomid@ph.ucla.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:68689c7c8ef85db355108a8fed12dcea265c063e22837db23e21bdd4f175eff7c30c22b748d14b0295bbbaba11e6e05ebf5b6e75495de7d3ed4c208ce0a1929d
• Download URL:
  https://stacks.cdc.gov/view/cdc/225164/cdc_225164_DS1.pdf
• File Type:
  [PDF - 162.28 KB ]