Urinary Metals and Adipokines in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Wang, Xin ; Karvonen-Gutierrez, Carrie A. ; Mukherjee, Bhramar ; Herman, William H. ; Kyun Park, Sung
• Description:
  Background:
  
  Information on the associations between metal exposures and adipokines in human populations is limited and results are inconsistent. We evaluated the associations between metals and adipokines.
  
  Methods:
  
  Urinary concentrations of 15 metals (arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc) were measured in 1999–2000 among 1,228 women of the Study of Women’s Health Across the Nation Multi-Pollutant Study. Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002–2003). Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard deviation increase in log-transformed urinary metal concentrations.
  
  Results:
  
  After adjustment for confounders, urinary molybdenum was associated with a 5.54% higher level (95% CI: 1.36%, 9.90%), whereas cadmium was associated with a 4.53% lower level (95% CI: −8.17%, −0.76%) of HMW-adiponectin. Urinary molybdenum was also associated with a 5.95% lower leptin level (95% CI: −10.15%, −1.56%) and a 2.98% (95% CI: 0.69%, 5.32%) higher sOB-R level. Urinary cesium and lead were associated with a 3.58% (95% CI: −6.06%, −1.03%) and a 2.53% (95% CI: −4.80%, −0.21%) lower level of sOB-R, respectively.
  
  Conclusions:
  
  Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles.
  
  
• Subjects:
  Adipokines Adiponectin Female Humans Leptin Metals Women's Health
• Keywords:
  Molybdenum Women
• Source:
  Environ Res. 196:110426
• Pubmed ID:
  33157106
• Pubmed Central ID:
  PMC8093324
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; P30 DK092926/DK/NIDDK NIH HHSUnited States/ ; U01 AG012554/AG/NIA NIH HHSUnited States/ ; UL1 RR024131/RR/NCRR NIH HHSUnited States/ ; T42OH008455/ACL/ACL HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; R21 HL091290/HL/NHLBI NIH HHSUnited States/ ; U01 AG012535/AG/NIA NIH HHSUnited States/ ; U01 AG012553/AG/NIA NIH HHSUnited States/ ; U01 NR004061/NR/NINR NIH HHSUnited States/ ; U01 AG012539/AG/NIA NIH HHSUnited States/ ; R01 ES026578/ES/NIEHS NIH HHSUnited States/ ; U01 AG012546/AG/NIA NIH HHSUnited States/ ; U19 AG063720/AG/NIA NIH HHSUnited States/ ; U01 AG012495/AG/NIA NIH HHSUnited States/ ; P30 DK020572/DK/NIDDK NIH HHSUnited States/ ; U01 AG012505/AG/NIA NIH HHSUnited States/ ; U01 AG012531/AG/NIA NIH HHSUnited States/ ; R01 ES026964/ES/NIEHS NIH HHSUnited States/ ; U01 AG017719/AG/NIA NIH HHSUnited States/
• Volume:
  196
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:852da320c9e8cc200856f0570b485f3ff0c7b01e81075324c83bf7540fbe3f79
• Download URL:
  https://stacks.cdc.gov/view/cdc/105953/cdc_105953_DS1.pdf
• File Type:
  [PDF - 350.83 KB ]