Urinary Metals and Adipokines in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)

Details

• Personal Author:
  Herman WH ; Karvonen-Gutierrez CA ; Mukherjee B ; Park SK ; Wang X
• Description:
  Background: Information on the associations between metal exposures and adipokines in human populations is limited and results are inconsistent. We evaluated the associations between metals and adipokines. Methods: Urinary concentrations of 15 metals (arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc) were measured in 1999-2000 among 1228 women of the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compute estimated percent changes in adipokines for one standard deviation increase in log-transformed urinary metal concentrations. Results: After adjustment for confounders, urinary molybdenum was associated with a 5.54% higher level (95% CI: 1.36%, 9.90%), whereas cadmium was associated with a 4.53% lower level (95% CI: -8.17%, -0.76%) of HMW-adiponectin. Urinary molybdenum was also associated with a 5.95% lower leptin level (95% CI: -10.15%, -1.56%) and a 2.98% (95% CI: 0.69%, 5.32%) higher sOB-R level. Urinary cesium and lead were associated with a 3.58% (95% CI: -6.06%, -1.03%) and a 2.53% (95% CI: -4.80%, -0.21%) lower level of sOB-R, respectively. Conclusions: Our findings suggest that molybdenum was associated with favorable profiles of HMW-adiponectin, leptin, and sOB-R. Exposures to cadmium, cesium, and lead were associated with adverse adipokine profiles. [Description provided by NIOSH]
• Subjects:
  Cadmium Cohort Studies Lead Metals Occupational Health Safety Women
• Keywords:
  Adipokines Adiponectin Author Keywords: Metals Cell Signaling Cohort Studies Cytokines Leptin Longitudinal Study Molybdenum Proteins
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  196
• NIOSHTIC Number:
  nn:20061722
• Citation:
  Environ Res 2021 May; 196:110426
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan, M5541 SPH II, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Cesium (CAS RN 7440-46-2) ; Lead (CAS RN 7439-92-1) ; Molybdenum (CAS RN 7439-98-7)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3dfa6b09e19b49350fab4c85bdedb0ccb43d6cfc802c8ec2f1c82e0f3033889c3722264d7717fac92614bf4dc0a6d80e85c472d6ef2336651aabebd9c27067f2
• Download URL:
  https://stacks.cdc.gov/view/cdc/225148/cdc_225148_DS1.pdf
• File Type:
  [PDF - 472.29 KB ]