Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Watkins, Anne E. ; Fenichel, Eli P. ; Weinberger, Daniel M. ; Vogels, Chantal B.F. ; Brackney, Doug E. ; Casanovas-Massana, Arnau ; Campbell, Melissa ; Fournier, John ; Bermejo, Santos ; Datta, Rupak ; Dela Cruz, Charles S. ; Farhadian, Shelli F. ; Iwasaki, Akiko ; Ko, Albert I. ; Grubaugh, Nathan D. ; Wyllie, Anne L.
• Corporate Authors:
  Yale IMPACT Research Team
• Description:
  We analyzed feasibility of pooling saliva samples for severe acute respiratory syndrome coronavirus 2 testing and found that sensitivity decreased according to pool size: 5 samples/pool, 7.4% reduction; 10 samples/pool, 11.1%; and 20 samples/pool, 14.8%. When virus prevalence is >2.6%, pools of 5 require fewer tests; when <0.6%, pools of 20 support screening strategies.
• Subjects:
  Capacity Building Coronavirus Infections Covid-19 Nucleic Acid Testing Health Care Rationing Humans Limit Of Detection Resource Allocation Saliva Sensitivity And Specificity Specimen Handling
• Source:
  Emerg Infect Dis. 27(4):1184-1187
• Pubmed ID:
  33755009
• Pubmed Central ID:
  PMC8007323
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Volume:
  27
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f71417377a48ef35523ae8495c4df4ad0b53e326d2aaa5108ef5c863c822dd8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/104873/cdc_104873_DS1.pdf
• File Type:
  [PDF - 1.75 MB ]