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CDC Public Access

CDC Stacks Public Health Publications

Items in this collection are manuscripts and articles written by CDC or CDC-funded authors, and published in scholarly journals outside CDC. These items are available in compliance with the 2024 update of CDC-GA-2013-01 CDC Public Access to CDC-Funded Publications, available at: https://stacks.cdc.gov/view/cdc/159734.

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Showing 25681 - 25700 of 27868 results
  • Vitamin A and immune regulation Role of retinoic acid in gutassociated dendritic cell education immune protection and tolerance
    Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance
    Cassani, Barbara ;
    Villablanca, Eduardo J.
    November 22 2011 | Mol Aspects Med. 2011; 33(1):63-76
    The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC) and is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA-ASC). Moreover, RA modulates Foxp3(+) regulatory T cell (T(REG)) and Th17 effector T cell different ...
    Supporting Files
  • Multiple Cytokines Are Released When Blood from Patients with Tuberculosis Is Stimulated with Mycobacterium tuberculosis Antigens
    Multiple Cytokines Are Released When Blood from Patients with Tuberculosis Is Stimulated with Mycobacterium tuberculosis Antigens
    Kellar, Kathryn L. ;
    Gehrke, Jennifer
    Nov 21 2011 | PLoS One. 2011; 6(11).
    BackgroundMycobacterium tuberculosis (Mtb) infection may cause overt disease or remain latent. Interferon gamma release assays (IGRAs) detect Mtb infection, both latent infection and infection manifesting as overt disease, by measuring whole-blood interferon gamma (IFN-γ) responses to Mtb antigens such as early secreted antigenic target-6 (ESAT-6), ...
    Supporting Files Public Domain
  • Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel
    Tailoring material properties of a nanofibrous extracellular matrix derived hydrogel
    Johnson, Todd D. ;
    Lin, Stephen Y.
    Nov 21 2011 | Nanotechnology. 22(49):494015.
    In the native tissue, the interaction between cells and the extracellular matrix (ECM) is essential for cell migration, proliferation, differentiation, mechanical stability, and signaling. It has been shown that decellularized ECMs can be processed into injectable formulations, thereby allowing for minimally invasive delivery. Upon injection and in ...
    Supporting Files
  • Clinical outcome of pneumococcal meningitis during the emergence of pencillinresistant Streptococcus pneumoniae an observational study
    Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
    Gouveia, Edilane L ;
    Reis, Joice N
    Nov 21 2011 | BMC Infect Dis. 2011; 11:323.
    BackgroundPrior to the availability of generic third-generation cephalosporins, penicillins were widely used for treatment of pneumococcal meningitis in developing countries despite concerns about rising levels of penicillin resistance among pneumococcal isolates. We examined the impact of penicillin resistance on outcomes of pneumococcal meningiti ...
    Supporting Files Public Domain
  • The Health of HIVexposed Children after Early Weaning
    The Health of HIV-exposed Children after Early Weaning
    Parker, Megan E. ;
    Tembo, Martin
    11 20 2011 | Matern Child Nutr. 9(2):217-232
    There are potential health risks associated with the use of early weaning to prevent mother-to-child transmission of human immunodeficiency virus (HIV) in resource-poor settings. Our objective was to examine growth and nutrient inadequacies among a cohort of children weaned early. Children participating in the Breastfeeding Antiretrovirals and Nutr ...
    Supporting Files
  • Random KNN feature selection a fast and stable alternative to Random Forests
    Random KNN feature selection - a fast and stable alternative to Random Forests
    Li, Shengqiao ;
    Harner, E James
    Nov 18 2011 | BMC Bioinformatics. 2011; 12:450.
    BackgroundSuccessfully modeling high-dimensional data involving thousands of variables is challenging. This is especially true for gene expression profiling experiments, given the large number of genes involved and the small number of samples available. Random Forests (RF) is a popular and widely used approach to feature selection for such "small n ...
    Supporting Files Public Domain
  • Speed Sensitivity and Bistability in Autoactivating Signaling Circuits
    Speed, Sensitivity, and Bistability in Auto-activating Signaling Circuits
    Hermsen, Rutger ;
    Erickson, David W.
    Nov 17 2011 | PLoS Comput Biol. 2011; 7(11).
    Cells employ a myriad of signaling circuits to detect environmental signals and drive specific gene expression responses. A common motif in these circuits is inducible auto-activation: a transcription factor that activates its own transcription upon activation by a ligand or by post-transcriptional modification. Examples range from the two-componen ...
    Supporting Files
  • PersontoPerson Transmission of Severe Fever With Thrombocytopenia Syndrome Bunyavirus Through Blood Contact
    Person-to-Person Transmission of Severe Fever With Thrombocytopenia Syndrome Bunyavirus Through Blood Contact
    Gai, Zhongtao ;
    Liang, Mifang
    Nov 17 2011 | Clin Infect Dis. 2011; 54(2):249-252.
    Severe fever with thrombocytopenia syndrome bunyavirus is a newly discovered bunyavirus with high pathogenicity to human. The transmission model has been largely uncharacterized. Investigation on a cluster of severe fever with thrombocytopenia syndrome cases provided evidence of person-to-person transmission through blood contact to the index patie ...
    Supporting Files Public Domain
  • Availability of physical activity resources in the environment for adults with intellectual disabilities
    Availability of physical activity resources in the environment for adults with intellectual disabilities
    Howie, Erin K. ;
    Barnes, Timothy L.
    November 17 2011 | Disabil Health J. 2011; 5(1):41-48
    BackgroundAdults with intellectual disabilities (ID) have high rates of physical inactivity, yet little is known about the prevalence of facilitators and barriers in the built environment contributing to these high rates.ObjectiveTo describe the physical activity resources available to adults with ID in both the home and day programs outside of the ...
    Supporting Files
  • ProviderInitiated HIV Testing and Counseling Increased Uptake in Two Public Community Health Centers in South Africa and Implications for ScaleUp
    Provider-Initiated HIV Testing and Counseling: Increased Uptake in Two Public Community Health Centers in South Africa and Implications for Scale-Up
    Dalal, Shona ;
    Lee, Chung-won
    Nov 17 2011 | PLoS One. 2011; 6(11).
    BackgroundInternational guidance recommends the scale up of routinely recommended, offered, and delivered health care provider-initiated HIV testing and counseling (PITC) to increase the proportion of persons who know their HIV status. We compared HIV test uptake under PITC to provider-referral to voluntary counseling and testing (VCT referral) in ...
    Supporting Files Public Domain
  • Mechanisms of crystalline silicainduced pulmonary toxicity revealed by global gene expression profiling
    Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling
    Sellamuthu, Rajendran ;
    Umbright, Christina
    Nov 16 2011 | Inhal Toxicol. 23(14):927-937.
    A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystal ...
    Supporting Files
  • Exposure to Repetitive Tasks Induces Motor Changes Related to Skill Acquisition and Inflammation in Rats
    Exposure to Repetitive Tasks Induces Motor Changes Related to Skill Acquisition and Inflammation in Rats
    Kietrys, David M. ;
    Barr, Ann E
    Nov 16 2011 | J Mot Behav. 43(6):465-476.
    The authors elucidate exposure-response relationships between repetitive tasks, inflammation, and motor changes with work-related musculoskeletal disorders. Using a rat model of reaching and handle pulling, they examined effects of performing a high-repetition, low-force (HRLF); low-repetition, high-force (LRHF); or high-repetition, high-force (HRH ...
    Supporting Files
  • A Novel Innate ImmuneEnhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia
    A Novel Innate Immune-Enhancement Strategy Combined with IVIG Rescues Mice from Fatal Staphylococcus aureus Septicemia
    Rajam, Gowrisankar ;
    Hammons, Gabrielle M.
    Nov 16 2011 | Int J Microbiol. 2011; 2011.
    Staphylococcus aureus (SA) is a major community-acquired pathogen. The emergence of drug-resistant strains like, methicillin-resistant SA (MRSA), poses stiff challenges to therapeutic intervention. Passive immune-therapy with specific antibodies is being actively examined to treat fulminant infections with limited success. In this study, we demonst ...
    Supporting Files Public Domain
  • Conjoined Twins A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research
    Conjoined Twins: A Worldwide Collaborative Epidemiological Study of the International Clearinghouse for Birth Defects Surveillance and Research
    MUTCHINICK, OSVALDO M. ;
    LUNA-MUÑOZ, LEONORA
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):274-287
    Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, ...
    Supporting Files
  • Sirenomelia An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research and Literature Review
    Sirenomelia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research, and Literature Review
    ORIOLI, IÊDA M. ;
    AMAR, EMMANUELLE
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):358-373
    Sirenomelia is a very rare limb anomaly in which the normally paired lower limbs are replaced by a single midline limb. This study describes the prevalence, associated malformations, and maternal characteristics among cases with sirenomelia. Data originated from 19 birth defect surveillance system members of the International Clearinghouse for Birt ...
    Supporting Files
  • Phocomelia A Worldwide Descriptive Epidemiologic Study in a Large Series of Cases From the International Clearinghouse for Birth Defects Surveillance and Research and Overview of the Literature
    Phocomelia: A Worldwide Descriptive Epidemiologic Study in a Large Series of Cases From the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature
    Bermejo-Sánchez, Eva ;
    Cuevas, Lourdes
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):305-320
    Epidemiologic data on phocomelia are scarce. This study presents an epidemiologic analysis of the largest series of phocomelia cases known to date. Data were provided by 19 birth defect surveillance programs, all members of the International Clearinghouse for Birth Defects Surveillance and Research. Depending on the program, data corresponded to a ...
    Supporting Files
  • Amelia A MultiCenter Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research and Overview of the Literature
    Amelia: A Multi-Center Descriptive Epidemiologic Study in a Large Dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and Overview of the Literature
    BERMEJO-SÁNCHEZ, EVA ;
    CUEVAS, LOURDES
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):288-304
    This study describes the epidemiology of congenital amelia (absence of limb/s), using the largest series of cases known to date. Data were gathered by 20 surveillance programs on congenital anomalies, all International Clearinghouse for Birth Defects Surveillance and Research members, from all continents but Africa, from 1968 to 2006, depending on ...
    Supporting Files
  • Cyclopia An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research
    Cyclopia: An Epidemiologic Study in a Large Dataset From the International Clearinghouse of Birth Defects Surveillance and Research
    Orioli, Iêda M. ;
    Amar, Emmanuelle
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):344-357
    Cyclopia is characterized by the presence of a single eye, with varying degrees of doubling of the intrinsic ocular structures, located in the middle of the face. It is the severest facial expression of the holoprosencephaly (HPE) spectrum. This study describes the prevalence, associated malformations, and maternal characteristics among cases with ...
    Supporting Files
  • Platypus TCR provides insight into the origins and evolution of a uniquely mammalian TCR locus1
    Platypus TCRμ provides insight into the origins and evolution of a uniquely mammalian TCR locus1
    Wang, Xinxin ;
    Parra, Zuly E.
    11 15 2011 | J Immunol. 187(10):5246-5254
    TCRμ is an unconventional TCR that was first discovered in marsupials and appears to be absent from placental mammals and nonmammals. In this study, we show that TCRμ is also present in the duckbill platypus, an egg-laying monotreme, consistent with TCRμ being ancient and present in the last common ancestor of all extant mammals. As in marsupials, ...
    Supporting Files
  • Bladder Exstrophy An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research and an Overview of the Literature
    Bladder Exstrophy: An Epidemiologic Study From the International Clearinghouse for Birth Defects Surveillance and Research, and an Overview of the Literature
    SIFFEL, CSABA ;
    CORREA, ADOLFO
    11 15 2011 | Am J Med Genet C Semin Med Genet. 2011; 0(4):321-332
    Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalence, and maternal and case characteristics of BE. We used data from 22 participating member programs of t ...
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