Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

Details

• Alternative Title:
  Mol Aspects Med
• Personal Author:
  Cassani, Barbara ; Villablanca, Eduardo J. ; De Calisto, Jaime ; Wang, Sen ; Mora, J. Rodrigo
• Description:
  The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC) and is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA-ASC). Moreover, RA modulates Foxp3(+) regulatory T cell (T(REG)) and Th17 effector T cell differentiation. Thus, although RA could be used as an effective "mucosal adjuvant" in vaccines, it also appears to be required for establishing intestinal immune tolerance. Here we discuss the roles proposed for RA in shaping intestinal immune responses and tolerance at the gut mucosal interface. We also focus on recent data exploring the mechanisms by which gut-associated DC acquire RA-producing capacity.
• Subjects:
  Adjuvants, Immunologic Animals Article B-Lymphocytes Cell Differentiation Dendritic Cells Homing Humans Immune Tolerance Immunity, Mucosal Intestines Retinoic Acid T-Lymphocytes Tolerance Tretinoin Vitamin A

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• Source:
  Mol Aspects Med. 2011; 33(1):63-76
• Pubmed ID:
  22120429
• Pubmed Central ID:
  PMC3246074
• Document Type:
  Journal Article
• Funding:
  DP2 OD006512-01/OD/NIH HHS/United States ; P30 AR042689/AR/NIAMS NIH HHS/United States ; DP2 2009A054301/DP/NCCDPHP CDC HHS/United States
• Volume:
  33
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0e0087b92e7fc0e258a682641fc0d2db2a206b699cd98fdfed402591670bc72f
• Download URL:
  https://stacks.cdc.gov/view/cdc/33287/cdc_33287_DS1.pdf
• File Type:
  [PDF - 435.48 KB ]