Details:

Alternative Title:
Mol Aspects Med
Personal Author:
Cassani, Barbara ; Villablanca, Eduardo J. ; De Calisto, Jaime ; Wang, Sen ; Mora, J. Rodrigo
Cassani, Barbara ; Villablanca, Eduardo J. ; De Calisto, Jaime ; Wang, Sen ; Mora, J. Rodrigo Less -
Description:
The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC) and is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA-ASC). Moreover, RA modulates Foxp3(+) regulatory T cell (T(REG)) and Th17 effector T cell differentiation. Thus, although RA could be used as an effective "mucosal adjuvant" in vaccines, it also appears to be required for establishing intestinal immune tolerance. Here we discuss the roles proposed for RA in shaping intestinal immune responses and tolerance at the gut mucosal interface. We also focus on recent data exploring the mechanisms by which gut-associated DC acquire RA-producing capacity.
Subjects:
[+]
Adjuvants, Immunologic Animals Article B-Lymphocytes Cell Differentiation Dendritic Cells Homing Humans Immune Tolerance Immunity, Mucosal Intestines Retinoic Acid T-Lymphocytes Tolerance Tretinoin Vitamin A
Source:
Mol Aspects Med. 2011; 33(1):63-76
Pubmed ID:
22120429
Pubmed Central ID:
PMC3246074
Document Type:
Journal Article
Funding:
DP2 OD006512-01/OD/NIH HHS/United States ; P30 AR042689/AR/NIAMS NIH HHS/United States ; DP2 2009A054301/DP/NCCDPHP CDC HHS/United States
DP2 OD006512-01/OD/NIH HHS/United States ; P30 AR042689/AR/NIAMS NIH HHS/United States ; DP2 2009A054301/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0e0087b92e7fc0e258a682641fc0d2db2a206b699cd98fdfed402591670bc72f
Download URL:
https://stacks.cdc.gov/view/cdc/33287/cdc_33287_DS1.pdf
File Type:

Supporting Files

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