Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Solomon, Isaac H. ; Ganesh, Vijay S. ; Yu, Guixia ; Deng, Xian Ding ; Wilson, Michael R. ; Miller, Steve ; Milligan, Tracey A. ; Mukerji, Shibani S. ; Mathewson, Abigail ; Linxweiler, Justin ; Morse, Darlene ; Ritter, Jana M. ; Staples, J. Erin ; Hughes, Holly ; Gould, Carolyn V. ; Sabeti, Pardis C. ; Chiu, Charles Y. ; Piantadosi, Anne
• Description:
  A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
• Subjects:
  Arbovirus Dispatch Encephalitis Fatal Case Of Chronic Jamestown Canyon Virus Encephalitis Diagnosed By Metagenomic Sequencing In A Patient Receiving Rituximab Jamestown Canyon Virus Metagenomic Next-generation Sequencing Monoclonal Antibody Orthobunyavirus Rituximab Vector-borne Infections Viruses

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• Source:
  Emerg Infect Dis. 27(1):238-242
• Pubmed ID:
  33261720
• Pubmed Central ID:
  PMC7774567
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b50b3493dc68c16e0a4e8cacd963e101ef1db9393f296fc3917135f3626fe722
• Download URL:
  https://stacks.cdc.gov/view/cdc/99998/cdc_99998_DS1.pdf
• File Type:
  [PDF - 2.12 MB ]