Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Solomon, Isaac H. ; Ganesh, Vijay S. ; Yu, Guixia ; Deng, Xian Ding ; Wilson, Michael R. ; ... More +
Solomon, Isaac H. ; Ganesh, Vijay S. ; Yu, Guixia ; Deng, Xian Ding ; Wilson, Michael R. ; Miller, Steve ; Milligan, Tracey A. ; Mukerji, Shibani S. ; Mathewson, Abigail ; Linxweiler, Justin ; Morse, Darlene ; Ritter, Jana M. ; Staples, J. Erin ; Hughes, Holly ; Gould, Carolyn V. ; Sabeti, Pardis C. ; Chiu, Charles Y. ; Piantadosi, Anne Less -
Description:
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
Subject:
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Arbovirus Dispatch Encephalitis Fatal Case Of Chronic Jamestown Canyon Virus Encephalitis Diagnosed By Metagenomic Sequencing In A Patient Receiving Rituximab Jamestown Canyon Virus Metagenomic Next-generation Sequencing Monoclonal Antibody Orthobunyavirus Rituximab Vector-borne Infections Viruses
Source:
Emerg Infect Dis. 27(1):238-242
Pubmed ID:
33261720
Pubmed Central ID:
PMC7774567
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:b50b3493dc68c16e0a4e8cacd963e101ef1db9393f296fc3917135f3626fe722
Download URL:
https://stacks.cdc.gov/view/cdc/99998/cdc_99998_DS1.pdf
File Type:

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