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Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab
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Published Date:
December 01 2020
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Source:Emerg Infect Dis. 27(1):238-242
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Language:English
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Details:
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
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Subject:
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Pubmed ID:33261720
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Pubmed Central ID:PMC7774567
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