IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Staines, Henry M.; Kirwan, Daniela E.; Clark, David J.; Adams, Emily R.; Augustin, Yolanda; Byrne, Rachel L.; Cocozza, Michael; Cubas-Atienzar, Ana I.; Cuevas, Luis E.; Cusinato, Martina; Davies, Benedict M.O.; Davis, Mark; Davis, Paul; Duvoix, Annelyse; Eckersley, Nicholas M.; Forton, Daniel; Fraser, Alice J.; Garrod, Gala; Hadcocks, Linda; Hu, Qinxue; Johnson, Michael; Kay, Grant A.; Klekotko, Kesja; Lewis, Zawditu; Macallan, Derek C.; Mensah-Kane, Josephine; Menzies, Stefanie; Monahan, Irene; Moore, Catherine M.; Nebe-von-Caron, Gerhard; Owen, Sophie I.; Sainter, Chris; Sall, Amadou A.; Schouten, James; Williams, Christopher T.; Wilkins, John; Woolston, Kevin; Fitchett, Joseph R.A.; Krishna, Sanjeev; Planche, Tim

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IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Supporting Files Public Domain

November 30 2020
By Staines, Henry M. ; Kirwan, Daniela E. ; Clark, David J. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Staines, Henry M. ; Kirwan, Daniela E. ; Clark, David J. ; Adams, Emily R. ; Augustin, Yolanda ; Byrne, Rachel L. ; Cocozza, Michael ; Cubas-Atienzar, Ana I. ; Cuevas, Luis E. ; Cusinato, Martina ; Davies, Benedict M.O. ; Davis, Mark ; Davis, Paul ; Duvoix, Annelyse ; Eckersley, Nicholas M. ; Forton, Daniel ; Fraser, Alice J. ; Garrod, Gala ; Hadcocks, Linda ; Hu, Qinxue ; Johnson, Michael ; Kay, Grant A. ; Klekotko, Kesja ; Lewis, Zawditu ; Macallan, Derek C. ; Mensah-Kane, Josephine ; Menzies, Stefanie ; Monahan, Irene ; Moore, Catherine M. ; Nebe-von-Caron, Gerhard ; Owen, Sophie I. ; Sainter, Chris ; Sall, Amadou A. ; Schouten, James ; Williams, Christopher T. ; Wilkins, John ; Woolston, Kevin ; Fitchett, Joseph R.A. ; Krishna, Sanjeev ; Planche, Tim
Description:

We investigated the dynamics of seroconversion in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. During March 29-May 22, 2020, we collected serum samples and associated clinical data from 177 persons in London, UK, who had SARS-CoV-2 infection. We measured IgG against SARS-CoV-2 and compared antibody levels with patient outcomes, demographic information, and laboratory characteristics. We found that 2.0%-8.5% of persons did not seroconvert 3-6 weeks after infection. Persons who seroconverted were older, were more likely to have concurrent conditions, and had higher levels of inflammatory markers. Non-White persons had higher antibody concentrations than those who identified as White; these concentrations did not decline during follow-up. Serologic assay results correlated with disease outcome, race, and other risk factors for severe SARS-CoV-2 infection. Serologic assays can be used in surveillance to clarify the duration and protective nature of humoral responses to SARS-CoV-2 infection.
Subjects:

Adult Aged Antibodies, Viral Coronavirus Infections COVID-19 Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G Male Middle Aged SARS-CoV-2 Seroconversion
Source:

Emerg Infect Dis. 27(1):85-91
Pubmed ID:

33256890
Pubmed Central ID:

PMC7774532
Document Type:

Journal Article
Volume:

27
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:bae8de3f99715280f53f6e54925826f92c0c6a02cdde9ac5dc5c73302e9cb358
Download URL:

https://stacks.cdc.gov/view/cdc/99987/cdc_99987_DS1.pdf
File Type:

[PDF - 917.45 KB ]

File Language:

English

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