Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Anh, Nguyen To ; Nhu, Le Nguyen Truc ; Hong, Nguyen Thi Thu ; Phuc, Tran My ; Tam, Pham Thi Thanh ; ... More +
Anh, Nguyen To ; Nhu, Le Nguyen Truc ; Hong, Nguyen Thi Thu ; Phuc, Tran My ; Tam, Pham Thi Thanh ; Huong, Dang Thao ; Anh, Tran Tuan ; Deng, Xutao ; Nghia, Ho Dang Trung ; Nguyen, Tran Thua ; Van Hung, Nguyen ; Thuan, Nguyen Dac ; Phuong, Pham Thi Hong ; Chau, Nguyen Van Vinh ; Baker, Stephen ; Delwart, Eric ; Thwaites, Guy ; Van Tan, Le ; Less -
Corporate Authors:
for the VIZIONS Consortium1 ;
Description:
Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid (CSF) samples from patients with acute CNS infection who were enrolled from Vietnam hospitals during 2012-2016. We detected 8 viral species in 107/204 (52.4%) of CSF samples. After virus-specific PCR confirmation, the detection rate was lowered to 30/204 (14.7%). Enteroviruses were the most common viruses detected (n = 23), followed by hepatitis B virus (3), HIV (2), molluscum contagiosum virus (1), and gemycircularvirus (1). Analysis of enterovirus sequences revealed the predominance of echovirus 30 (9). Phylogenetically, the echovirus 30 strains belonged to genogroup V and VIIb. Our results expanded knowledge about the clinical burden of enterovirus in Vietnam and underscore the challenges of identifying a plausible viral pathogen in CSF of patients with CNS infections.
Subject:
[+]
Central Nervous System Infections
Cerebrospinal Fluid
Enterovirus
Enterovirus Infections
Humans
Metagenomics

Source:
Emerg Infect Dis. 27(1):205-213 ;
Pubmed ID:
33350920
Pubmed Central ID:
PMC7774551
Document Type:
Journal Article ;
Place as Subject:
Vietnam ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:aa3c52b28f19741a9c3ec1a6b63897b5c5278e55aa3eab255edc2186972b1046
File Type:

Supporting Files

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