Diabetic ketoacidosis (DKA) at diagnosis among youth with type 1 and type 2 diabetes: results from SEARCH (US) and YDR (India) registries

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Praveen, Pradeep A ; Hockett, Christine W ; Ong, Toan C ; Anandakumar, Amutha ; Isom, Scott P ; Jensen, Elizabeth T ; Mohan, Viswanathan ; Dabelea, Dana A ; D'Agostino, Ralph B ; Hamman, Richard F ; Mayer-Davis, Elizabeth J ; Lawrence, Jean M ; Dolan, Lawrence M. ; Kahn, Michael G ; Madhu, SV ; Tandon, Nikhil
• Description:
  Background:
  
  There is significant global variation in the prevalence of DKA at diagnosis among youth with T1D. However, data for youth with T2D are limited, even in developed countries. We compared the prevalence of DKA at diagnosis among individuals with T1D and T2D from the SEARCH for Diabetes in Youth (SEARCH) and the Registry of people with diabetes in India with young age at onset (YDR) registries.
  
  Methods:
  
  We harmonized the SEARCH and YDR data sets to the structure and terminology in the OMOP Common Data Model (v5). Data used in the analysis were from youth with T1D and T2D diagnosed before 20 years and newly diagnosed between 2006 and 2012 in YDR and between 2009 and 2012 in SEARCH.
  
  Results:
  
  There were 5,366 U.S. youth (4,078 with T1D, 1,288 with T2D) and 2335 Indian youth (2108 with T1D, 227 with T2D). More than one third of T1D youth enrolled in SEARCH had DKA at diagnosis which was significantly higher than in YDR (35.3% vs 28.7%, p<0.0001). The burden of DKA in youth with T1D was significantly higher among younger age groups; this relationship was similar across registries (p=0.4). The prevalence of DKA among T2D in SEARCH and YDR were 5.5% and 6.6% respectively (p=0.4).
  
  Conclusions:
  
  There is significant burden of DKA at diagnosis with T1D among youth from U.S. and India, especially among the younger age groups. The reasons for this high prevalence are largely unknown but are critical to developing interventions to prevent DKA at diagnosis.
  
  
• Subjects:
  Article Diabetic Ketoacidois SEARCH For Diabetes In Youth Registry Type 1 Diabetes Type 2 Diabetes YDR Registry
• Source:
  Pediatr Diabetes. 22(1):40-46
• Pubmed ID:
  31943641
• Pubmed Central ID:
  PMC7748377
• Document Type:
  Journal Article
• Funding:
  UL1 TR00423/TR/NCATS NIH HHS/United States ; P30 DK57516/NH/NIH HHS/United States ; U48/CCU919219/CC/CDC HHS/United States ; U48/CCU819241-3/CC/CDC HHS/United States ; U18DP006134/CC/CDC HHS/United States ; R21 DK105869/DK/NIDDK NIH HHS/United States ; U18DP000247-06A1/CC/CDC HHS/United States ; U18DP002708/CC/CDC HHS/United States ; R21DK105869-02/NH/NIH HHS/United States ; U18DP006138/CC/CDC HHS/United States ; U48/CCU519239/CC/CDC HHS/United States ; UL1 Tr001450/TR/NCATS NIH HHS/United States ; 00097/CC/CDC HHS/United States ; U18DP002714/CC/CDC HHS/United States ; U48/CCU419249/CC/CDC HHS/United States ; 1U18DP002709/CC/CDC HHS/United States ; U58/CCU019235-4/CC/CDC HHS/United States ; U18DP002710-01/CC/CDC HHS/United States ; U18DP006136/CC/CDC HHS/United States ; DP-10-001/CC/CDC HHS/United States ; U18DP006139/CC/CDC HHS/United States ; 200-2010-35171/CC/CDC HHS/United States ; U18DP006133/CC/CDC HHS/United States ; DP-05-069/CC/CDC HHS/United States ; R01 DK127208/DK/NIDDK NIH HHS/United States ; 1U18DP006131/CC/CDC HHS/United States
• Volume:
  22
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7a2dc5b05a07ab90ff020e59cf2291ccb35b19d623694de6ff5ee7f04202edab
• Download URL:
  https://stacks.cdc.gov/view/cdc/99054/cdc_99054_DS1.pdf
• File Type:
  [PDF - 209.15 KB ]