Details:

Alternative Title:
Am J Gastroenterol
Personal Author:
Melkonian, Stephanie C. ; Pete, Dornell ; Jim, Melissa A. ; Haverkamp, Donald ; Wiggins, Charles L. ; ... More +
Melkonian, Stephanie C. ; Pete, Dornell ; Jim, Melissa A. ; Haverkamp, Donald ; Wiggins, Charles L. ; Bruce, Michael G. ; White, Mary C. Less -
Description:
Objectives:

American Indian and Alaska Native (AI/AN) populations have higher gastric cancer rates than the general U.S. population. This study provides a comprehensive overview of incidence rates among AI/AN persons during 2005–2016 compared with non-Hispanic whites (whites).

Methods:

Population-based cancer registry data for 2005–2016 were linked with the Indian Health Service (IHS) patient registration databases to address racial misclassification. Age-adjusted gastric cancer incidence rates were expressed per 100,000 per year. Incidence and trend analyses were restricted to purchased/referred care delivery area (PRCDA) counties in 6 geographic regions, comparing gastric cancer incidence rates for AI/AN versus white populations in the U.S.

Results:

Gastric cancer rates were higher in the AI/AN compared to white populations in nearly every U.S. region. Incidence rates for central/distal portions of the stomach were higher in AI/AN individuals compared to whites. Rates of later stage gastric cancer were higher in AI/AN populations overall and in every region except the Pacific Coast and East. Incidence rates decreased significantly over time in both populations. Declining rates in the AI/AN populations were driven by changes in the Pacific Coast and Northern Plains regions.

Conclusions:

AI/AN populations have a disproportionately high incidence of gastric cancer, especially in Alaska. High incidence in the central/distal portions of the stomach among AI/AN populations likely reflects a high prevalence of Helicobacter pylori infection in these populations. These data can be used to develop interventions to reduce risk factors and improve access to health services among AI/AN peoples at high risk for gastric cancer.


Subjects:
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Adult Aged Aged, 80 And Over Alaska Natives American Indians Or Alaska Natives Female Helicobacter Infections Humans Incidence Male Middle Aged Prevalence Registries Stomach Neoplasms
Source:
Am J Gastroenterol. 115(12):1989-1997
Pubmed ID:
32740090
Pubmed Central ID:
PMC7710924
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN261201800014C/CA/NCI NIH HHSUnited States/ ; HHSN261201800014I/CA/NCI NIH HHSUnited States/ ; T32 CA009168/CA/NCI NIH HHSUnited States/
CC999999/ImCDC/Intramural CDC HHSUnited States/ ; HHSN261201800014C/CA/NCI NIH HHSUnited States/ ; HHSN261201800014I/CA/NCI NIH HHSUnited States/ ; T32 CA009168/CA/NCI NIH HHSUnited States/ Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c797c9f884c414082f3c2d8607d3ed76903549368148c5f9cb76efdf548ac6ee
Download URL:
https://stacks.cdc.gov/view/cdc/98473/cdc_98473_DS1.pdf
File Type:

Supporting Files

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  	NIHMS1606840-supplement-Supplementary_Figures_and_Tables.docx	docx

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