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Gastric Cancer Among American Indian and Alaska Native Populations in the United States, 2005–2016
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12 2020
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Source: Am J Gastroenterol. 115(12):1989-1997
[PDF-792.10 KB]
Details:
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Alternative Title:Am J Gastroenterol
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Personal Author:
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Description:Objectives:
American Indian and Alaska Native (AI/AN) populations have higher gastric cancer rates than the general U.S. population. This study provides a comprehensive overview of incidence rates among AI/AN persons during 2005–2016 compared with non-Hispanic whites (whites).
Methods:
Population-based cancer registry data for 2005–2016 were linked with the Indian Health Service (IHS) patient registration databases to address racial misclassification. Age-adjusted gastric cancer incidence rates were expressed per 100,000 per year. Incidence and trend analyses were restricted to purchased/referred care delivery area (PRCDA) counties in 6 geographic regions, comparing gastric cancer incidence rates for AI/AN versus white populations in the U.S.
Results:
Gastric cancer rates were higher in the AI/AN compared to white populations in nearly every U.S. region. Incidence rates for central/distal portions of the stomach were higher in AI/AN individuals compared to whites. Rates of later stage gastric cancer were higher in AI/AN populations overall and in every region except the Pacific Coast and East. Incidence rates decreased significantly over time in both populations. Declining rates in the AI/AN populations were driven by changes in the Pacific Coast and Northern Plains regions.
Conclusions:
AI/AN populations have a disproportionately high incidence of gastric cancer, especially in Alaska. High incidence in the central/distal portions of the stomach among AI/AN populations likely reflects a high prevalence of Helicobacter pylori infection in these populations. These data can be used to develop interventions to reduce risk factors and improve access to health services among AI/AN peoples at high risk for gastric cancer.
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Pubmed ID:32740090
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Pubmed Central ID:PMC7710924
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Volume:115
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Issue:12
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