Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Lau, Susanna K.P.; Wong, Antonio C.P.; Luk, Hayes K.H.; Li, Kenneth S.M.; Fung, Joshua; He, Zirong; Cheng, Flora K.K.; Chan, Tony T.Y.; Chu, Stella; Aw-Yong, Kam Leng; Lau, Terrence C.K.; Fung, Kitty S.C.; Woo, Patrick C.Y.

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

July 30 2020
By Lau, Susanna K.P. ; Wong, Antonio C.P. ; Luk, Hayes K.H. ; ...
Source: Emerg Infect Dis. 26(12):2961-2965

[PDF-1.87 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Lau, Susanna K.P. ; Wong, Antonio C.P. ; Luk, Hayes K.H. ; Li, Kenneth S.M. ; Fung, Joshua ; ... More +

Lau, Susanna K.P. ; Wong, Antonio C.P. ; Luk, Hayes K.H. ; Li, Kenneth S.M. ; Fung, Joshua ; He, Zirong ; Cheng, Flora K.K. ; Chan, Tony T.Y. ; Chu, Stella ; Aw-Yong, Kam Leng ; Lau, Terrence C.K. ; Fung, Kitty S.C. ; Woo, Patrick C.Y. Less -
Description:

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Subjects:

[+]

Animals Chiroptera Coronavirus Infections COVID-19 Humans Middle East Respiratory Syndrome Coronavirus Pandemics SARS-CoV-2 SARS Virus Viral Tropism Virus Replication
Source:

Emerg Infect Dis. 26(12):2961-2965
Pubmed ID:

32730733
Pubmed Central ID:

PMC7706959
Document Type:

Journal Article
Volume:

26
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:2739290b3b66a681c0d8a0036d5be13058addd79743c0043faf7d1e8d8987be4
Download URL:

https://stacks.cdc.gov/view/cdc/98441/cdc_98441_DS1.pdf
File Type:

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