Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Lau, Susanna K.P.; Wong, Antonio C.P.; Luk, Hayes K.H.; Li, Kenneth S.M.; Fung, Joshua; He, Zirong; Cheng, Flora K.K.; Chan, Tony T.Y.; Chu, Stella; Aw-Yong, Kam Leng; Lau, Terrence C.K.; Fung, Kitty S.C.; Woo, Patrick C.Y.

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Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells

Supporting Files Public Domain

July 30 2020
By Lau, Susanna K.P. ; Wong, Antonio C.P. ; Luk, Hayes K.H. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lau, Susanna K.P. ; Wong, Antonio C.P. ; Luk, Hayes K.H. ; Li, Kenneth S.M. ; Fung, Joshua ; He, Zirong ; Cheng, Flora K.K. ; Chan, Tony T.Y. ; Chu, Stella ; Aw-Yong, Kam Leng ; Lau, Terrence C.K. ; Fung, Kitty S.C. ; Woo, Patrick C.Y.
Description:

Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Subjects:

Animals Chiroptera Coronavirus Infections COVID-19 Humans Middle East Respiratory Syndrome Coronavirus Pandemics SARS-CoV-2 SARS Virus Viral Tropism Virus Replication
Source:

Emerg Infect Dis. 26(12):2961-2965
Pubmed ID:

32730733
Pubmed Central ID:

PMC7706959
Document Type:

Journal Article
Volume:

26
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:2739290b3b66a681c0d8a0036d5be13058addd79743c0043faf7d1e8d8987be4
Download URL:

https://stacks.cdc.gov/view/cdc/98441/cdc_98441_DS1.pdf
File Type:

[PDF - 1.87 MB ]

File Language:

English

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