Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine against Invasive Pneumococcal Disease in Adults, Japan, 2013–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Shimbashi, Reiko ; Suzuki, Motoi ; Chang, Bin ; Watanabe, Hiroshi ; Tanabe, Yoshinari ; Kuronuma, Koji ; Oshima, Kengo ; Maruyama, Takaya ; Takeda, Hiroaki ; Kasahara, Kei ; Fujita, Jiro ; Nishi, Junichiro ; Kubota, Tetsuya ; Tanaka-Taya, Keiko ; Matsui, Tamano ; Sunagawa, Tomimasa ; Oishi, Kazunori
• Corporate Authors:
  Adult IPD Study Group
• Description:
  The decline in the proportion of pneumococcal conjugate vaccine (PCV)-covered serotypes among adult invasive pneumococcal disease (IPD) patients might change the overall effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) because its effectiveness differs according to serotype. Using the indirect cohort method, we calculated the effectiveness of PPSV23 against IPD among adults in Japan to assess the impact of the national pediatric PCV program. Clinical and epidemiologic information and pneumococcal isolates were collected from IPD patients >20 years of age through enhanced IPD surveillance during April 2013-December 2017. Adjusted effectiveness against PPSV23-serotype IPD was 42.2%. Despite a substantial decline in the proportion of 13-valent PCV serotypes during the study period (45% to 31%), the change in effectiveness for PPSV23-serotype IPD was limited (47.1% to 39.3%) and only marginal in the elderly population (39.9% to 39.4%). The pediatric PCV program had limited impact on PPSV23 effectiveness against IPD in adults.
• Subjects:
  23-valent Pneumococcal Polysaccharide Vaccine Indirect Cohort Method Indirect Effect Invasive Pneumococcal Disease IPD PPSV23 Research Respiratory Diseases Vaccine-preventable Diseases Vaccine Effectiveness
• Source:
  Emerg Infect Dis. 26(10):2378-2386
• Pubmed ID:
  32946721
• Pubmed Central ID:
  PMC7510723
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  26
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:36ce583e91568aadcdedbc8da2dcb6e49cb2b396d0abec3cfa4ed1a71ee7dfe8
• Download URL:
  https://stacks.cdc.gov/view/cdc/94747/cdc_94747_DS1.pdf
• File Type:
  [PDF - 598.65 KB ]