Follow-Up Study of Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine Against All-Type and Serotype-Specific Invasive Pneumococcal Disease, Denmark

Nielsen, Katrine Finderup; Nielsen, Lise Birk; Dalby, Tine; Lomholt, Frederikke Kristensen; Slotved, Hans-Christian; Fuursted, Kurt; Harboe, Zitta Barrella; Jørgensen, Charlotte Sværke; Valentiner-Branth, Palle

doi:10.3201/eid3006.230975

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Follow-Up Study of Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine Against All-Type and Serotype-Specific Invasive Pneumococcal Disease, Denmark

6-2024
By Nielsen, Katrine Finderup ; Nielsen, Lise Birk ; Dalby, Tine ; ...
http://dx.doi.org/10.3201/eid3006.230975
Source: Emerg Infect Dis. 2024; 30(6):1164-1172

[PDF-1.30 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Nielsen, Katrine Finderup ; Nielsen, Lise Birk ; Dalby, Tine ; Lomholt, Frederikke Kristensen ; Slotved, Hans-Christian ; ... More +

Nielsen, Katrine Finderup ; Nielsen, Lise Birk ; Dalby, Tine ; Lomholt, Frederikke Kristensen ; Slotved, Hans-Christian ; Fuursted, Kurt ; Harboe, Zitta Barrella ; Jørgensen, Charlotte Sværke ; Valentiner-Branth, Palle Less -
Description:

As a follow-up to a previous study, we investigated vaccine effectiveness (VE) of 23-valent pneumococcal polysaccharide vaccine (PPSV23) against invasive pneumococcal disease (IPD) among 1,254,498 persons >65 years of age as part of a vaccination program in Denmark during April 2020-January 2023. We assessed VE by using a Cox regression model and adjusted for age, sex, and underlying conditions. Using nationwide data, we estimated a VE of PPSV23 against all-type IPD of 32% and against PPSV23-serotype IPD of 41%. Because this follow-up study had more statistical power than the original study, we also estimated VE against IPD caused by PPSV23-serotypes excluding serotype 3; serotype 3; serotype 8; serotype 22F; PPSV23 non-PCV15 serotypes; PPSV23 non-PCV20 serotypes; and IPD over time. Our findings suggest PPSV23 vaccination can protect persons >65 years of age against IPD caused by all serotypes or serotype groupings, except serotype 3.
Subjects:

[+]

Aged Aged, 80 And Over Female Follow-Up Studies Humans Male Pneumococcal Infections Pneumococcal Vaccines Serogroup Streptococcus Pneumoniae Vaccination Vaccine Efficacy
Keywords:

[+]

23-valent Pneumococcal Polysaccharide Vaccine Bacteria Denmark Epidemiology Invasive Pneumococcal Disease Meningitis/Encephalitis Pneumococcal-conjugated Vaccines Pneumonia Public Health Programs Respiratory Infections Streptococci Vaccine Effectiveness
Source:

Emerg Infect Dis. 2024; 30(6):1164-1172
Pubmed ID:

38781925
Pubmed Central ID:

PMC11138992
Document Type:

Journal Article
Place as Subject:

Denmark
Volume:

30
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:fed4287b19d4178e1a48ac5feb4725d5f634ad302a25c4a9565557c7d2cac5ca
Download URL:

https://stacks.cdc.gov/view/cdc/156968/cdc_156968_DS1.pdf
File Type:

	23-0975-F.gif	gif
	23-0975-F.jpg	jpeg
	23-0975-Techapp-s1.pdf	pdf
	23-0975.nxml	xml

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