Drug Resistance Spread in 6 Metropolitan Regions, Germany, 2001–20181

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Stecher, Melanie ; Chaillon, Antoine ; Stephan, Christoph ; Knops, Elena ; Kohmer, Niko ; Lehmann, Clara ; Eberle, Josef ; Bogner, Johannes ; Spinner, Christoph D. ; Eis-Hübinger, Anna Maria ; Wasmuth, Jan-Christian ; Schäfer, Guido ; Behrens, Georg ; Mehta, Sanjay R. ; Vehreschild, Jörg Janne ; Hoenigl, Martin
• Description:
  We analyzed 1,397 HIV-1 pol sequences of antiretroviral therapy-naive patients in a total of 7 university hospitals in Bonn, Cologne, Frankfurt, Hamburg, Hannover, and Munich, Germany. Phylogenetic and network analysis elucidated numerous cases of shared drug resistance mutations among genetically linked patients; K103N was the most frequently shared mutation.
• Subjects:
  Antimicrobial Resistance Antiretroviral Therapy ART Dispatch HIV Transmission Mutations Phylogenetic Analysis Public Health
• Source:
  Emerg Infect Dis. 26(10):2439-2443
• Pubmed ID:
  32946725
• Pubmed Central ID:
  PMC7510719
• Document Type:
  Journal Article
• Funding:
  P30 AI036214/AI/NIAID NIH HHS/United States ; R21 MH113477/MH/NIMH NIH HHS/United States ; R24 AI106039/AI/NIAID NIH HHS/United States
• Place as Subject:
  Germany
• Location:
  Europe
• Volume:
  26
• Issue:
  10
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:f68832a31e8eed3dbe6af6f28a7af0f8a6d17ce486d85b0f45e0ead48291d584
• Download URL:
  https://stacks.cdc.gov/view/cdc/94746/cdc_94746_DS1.pdf
• File Type:
  [PDF - 1.29 MB ]