High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

Dziuban, Eric J.; DeVos, Joshua; Ngeno, Bernadette; Ngugi, Evelyn; Zhang, Guoqing; Sabatier, Jennifer; Wagar, Nick; Diallo, Karidia; Nganga, Lucy; Katana, Abraham; Yang, Chunfu; Rivadeneira, Emilia D.; Mukui, Irene; Odhiambo, Francesca; Redfield, Robert; Raizes, Elliot

doi:10.1097/INF.0000000000001597

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High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

8 2017
By Dziuban, Eric J. ; DeVos, Joshua ; Ngeno, Bernadette ; ...
http://dx.doi.org/10.1097/INF.0000000000001597
Source: Pediatr Infect Dis J. 36(8):758-760

[PDF-289.79 KB]

English

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Details:

Alternative Title:

Pediatr Infect Dis J
Personal Author:

Dziuban, Eric J. ; DeVos, Joshua ; Ngeno, Bernadette ; Ngugi, Evelyn ; Zhang, Guoqing ; ... More +

Dziuban, Eric J. ; DeVos, Joshua ; Ngeno, Bernadette ; Ngugi, Evelyn ; Zhang, Guoqing ; Sabatier, Jennifer ; Wagar, Nick ; Diallo, Karidia ; Nganga, Lucy ; Katana, Abraham ; Yang, Chunfu ; Rivadeneira, Emilia D. ; Mukui, Irene ; Odhiambo, Francesca ; Redfield, Robert ; Raizes, Elliot Less -
Description:

A survey of 461 HIV-infected Kenyan children receiving antiretroviral therapy found 143 (31%) failing virologically. Drug resistance mutations were found in 121; 37 had L74V/I mutations, with 95% receiving abacavir (ABC)-containing regimens. L74V/I was associated with current ABC usage (P = 0.0001). L74V/I may be more prevalent than previously realized in children failing ABC-containing regimens, even when time on treatment has been short. Ongoing rigorous pediatric drug resistance surveillance is needed.
Subjects:

[+]

Anti-HIV Agents Child Child, Preschool Cross-Sectional Studies Dideoxynucleosides Drug Resistance, Viral HIV-1 HIV Infections Humans Treatment Failure
Keywords:

[+]

Abacavir Antiretroviral Therapy HIV Drug-related Mutations Pediatrics
Source:

Pediatr Infect Dis J. 36(8):758-760
Pubmed ID:

28383390
Pubmed Central ID:

PMC6404536
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/ ; PEPFAR/PEPFARUnited States/

CC999999/Intramural CDC HHSUnited States/ ; PEPFAR/PEPFARUnited States/ Less -
Place as Subject:

Kenya
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:825744a75e813903c83d477031581acc143ea990da45dd67ca2ebeb318324d6e
Download URL:

https://stacks.cdc.gov/view/cdc/76380/cdc_76380_DS1.pdf
File Type:

nihms-1014593.nxml

xml

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