High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Dziuban, Eric J. ; DeVos, Joshua ; Ngeno, Bernadette ; Ngugi, Evelyn ; Zhang, Guoqing ; Sabatier, Jennifer ; Wagar, Nick ; Diallo, Karidia ; Nganga, Lucy ; Katana, Abraham ; Yang, Chunfu ; Rivadeneira, Emilia D. ; Mukui, Irene ; Odhiambo, Francesca ; Redfield, Robert ; Raizes, Elliot
• Description:
  A survey of 461 HIV-infected Kenyan children receiving antiretroviral therapy found 143 (31%) failing virologically. Drug resistance mutations were found in 121; 37 had L74V/I mutations, with 95% receiving abacavir (ABC)-containing regimens. L74V/I was associated with current ABC usage (P = 0.0001). L74V/I may be more prevalent than previously realized in children failing ABC-containing regimens, even when time on treatment has been short. Ongoing rigorous pediatric drug resistance surveillance is needed.
• Subjects:
  Anti-HIV Agents Child Child, Preschool Cross-Sectional Studies Dideoxynucleosides Drug Resistance, Viral HIV-1 HIV Infections Humans Treatment Failure
• Keywords:
  Abacavir Antiretroviral Therapy HIV Drug-related Mutations Pediatrics
• Source:
  Pediatr Infect Dis J. 36(8):758-760
• Pubmed ID:
  28383390
• Pubmed Central ID:
  PMC6404536
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/ ; PEPFAR/PEPFARUnited States/
• Place as Subject:
  Kenya
• Volume:
  36
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:825744a75e813903c83d477031581acc143ea990da45dd67ca2ebeb318324d6e
• Download URL:
  https://stacks.cdc.gov/view/cdc/76380/cdc_76380_DS1.pdf
• File Type:
  [PDF - 289.79 KB ]