Modeling regional transmission and containment of a healthcare-associated multidrug-resistant organism
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Help
Clear All

Query Builder

Query box

Help
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Modeling regional transmission and containment of a healthcare-associated multidrug-resistant organism

Filetype[PDF-639.70 KB]


  • English
    • Details Supporting Files You May Also Like

    Details:

    • Alternative Title:
      Clin Infect Dis
    • Personal Author:
    • Description:
      Background:

      CDC recently published Interim Guidance for a Public Health Response to Contain Novel or Targeted Multidrug-resistant Organisms (MDROs). We assessed the impact of implementing the strategy in a U.S. state using a mathematical model.

      Methods:

      We used a deterministic compartmental model, parametrized via a novel analysis of Carbapenem-resistant Enterobacteriaceae (CRE) data reported to the National Healthcare Safety Network and patient transfer data from the Center for Medicare & Medicaid Services. The simulations assumed that after the importation of the MDRO and its initial detection by clinical culture at an index hospital, fortnightly prevalence surveys for colonization and additional infection control interventions were implemented at the index facility; similar surveys were then also implemented at those facilities known to be connected most strongly to it as measured by patient transfer data; and, prevalence surveys were discontinued after two consecutive negative surveys.

      Results:

      If additional infection control interventions are assumed to lead to a 20% reduction in transmissibility in intervention facilities, prevalent case count in the state 3 years after importation would be reduced by 76% (IQR: 73%−77%). During the third year, these additional infection control measures would be applied in facilities accounting for 42% (37%−46%) of inpatient days.

      Conclusions:

      CDC guidance for containing MDROs, when used in combination with information on transfer of patients among hospitals, is predicted to be effective, enabling targeted and efficient use of prevention resources during an outbreak response. Even modestly effective infection control measures may lead to a substantial reduction in transmission events.

    • Subjects:
    • Source:
      Clin Infect Dis.
    • Pubmed ID:
      30919885
    • Pubmed Central ID:
      PMC6765447
    • Document Type:
      Journal Article
    • Funding:
      CC999999/ImCDC/Intramural CDC HHS/United States
    • Collection(s):
    • Main Document Checksum:
    • Download URL:
    • File Type:

    You May Also Like

    Checkout today's featured content at stacks.cdc.gov