Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes

Details

• Alternative Title:
  Genet Epidemiol
• Personal Author:
  Din, Lennox ; Sheikh, Mohammad ; Kosaraju, Nikitha ; Smedby, Karin E ; Bernatsky, Sasha ; Berndt, Sonja ; Skibola, Christine F ; Nieters, Alexandra ; Wang, Sophia ; McKay, James D ; Cocco, Pierluigi ; Maynadié, Marc ; Foretová, Lenka ; Staines, Anthony ; Mack, Thomas M ; de Sanjosé, Silvia ; Vyse, Timothy J. ; Padyukov, Leonid ; Taub, Zachary ; Din, Morris ; Monnereau, Alain ; Arslan, Alan A ; Moore, Amy ; Brooks-Wilson, Angela R ; Novak, Anne J ; Glimelius, Bengt ; Birmann, Brenda M ; Link, Brian K ; Stewart, Carolyn ; Vajdic, Claire M ; Haioun, Corinne ; Magnani, Corrado ; Conti, David ; Cox, David G ; Casabonne, Delphine ; Albanes, Demetrius ; Kane, Eleanor ; Roman, Eve ; Muzi, Giacomo ; Salles, Gilles ; Giles, Graham G ; Adami, Hans-Olov ; Ghesquières, Hervé ; Vivo, Immaculata De ; Clavel, Jacqueline ; Cerhan, James R ; Spinelli, John J ; Hofmann, Jonathan N ; Vijai, Joseph ; Curtin, Karen ; Costenbader, Karen H ; Onel, Kenan ; Offit, Kenneth ; Teras, Lauren R ; Morton, Lindsay M ; Conde, Lucia ; Miligi, Lucia ; Melbye, Mads ; Ennas, Maria Grazia ; Liebow, Mark ; Purdue, Mark P ; Glenn, Martha ; Southey, Melissa C ; Rothman, Nathaniel ; Camp, Nicola J ; Doo, Nicole Wong ; Becker, Nikolaus ; Pradhan, Nisha ; Bracci, Paige M ; Boffetta, Paolo ; Vineis, Paolo ; Brennan, Paul ; Kraft, Peter ; Lan, Qing ; Severson, Richard K ; Vermeulen, Roel C H ; Milne, Roger L ; Kaaks, Rudolph ; Travis, Ruth C ; Weinstein, Stephanie ; Chanock, Stephen J ; Ansell, Stephen M ; Slager, Susan L ; Zheng, Tongzhang ; Zhang, Yawei ; Benavente, Yolanda ; Madireddy, Lohith ; Gourraud, Pierre-Antoine ; Oksenberg, Jorge R ; Cozen, Wendy ; Hjalgrim, Henrik ; Khankhanian, Pouya
• Description:
  Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.
• Subjects:
  Alleles Article Autoimmune Disease Autoimmune Diseases Female Genetic Predisposition To Disease Genome-wide Association Study HLA Antigens Humans Lymphoma, Non-Hodgkin Male Meta-Analysis Middle Aged Multifactorial Inheritance Non-Hodgkin Lymphoma Polymorphism, Single Nucleotide Risk Factors

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• Source:
  Genet Epidemiol. 43(7):844-863
• Pubmed ID:
  31407831
• Pubmed Central ID:
  PMC6763347
• Document Type:
  Journal Article
• Funding:
  CA62006/CA/NCI NIH HHS/United States ; CA87969/NH/NIH HHS/United States ; CA098122, and CA134958/NH/NIH HHS/United States ; NS032830/NH/NIH HHS/United States ; P50 CA97274/James R Cerhan is supported by NIH grants/International ; RC4 AG039029/AG/NIA NIH HHS/United States ; NIH R01CA134674/Nicola Camp reports support from/International ; G1001799/MRC_/Medical Research Council/United Kingdom ; HHSN268201100001I/HL/NHLBI NIH HHS/United States ; P30 CA016087/CA/NCI NIH HHS/United States ; HHSN261201000140C/CA/NCI NIH HHS/United States ; N01 PC067010/PC/NCI NIH HHS/United States ; U01 HG004446/HG/NHGRI NIH HHS/United States ; R01 CA098122/CA/NCI NIH HHS/United States ; U01 HG007033/HG/NHGRI NIH HHS/United States ; U01 CA195568/CA/NCI NIH HHS/United States ; R01 CA133996/CA/NCI NIH HHS/United States ; NS19142/NH/NIH HHS/United States ; P30 CA42014/Partial support for all datasets within the UPDB is provided by the Huntsman Cancer Institute (HCI) and the HCI Comprehensive Cancer Center Support grant/International ; P50 CA097007/CA/NCI NIH HHS/United States ; R01CA201407/David Conti is supported by the following NIH/International ; U01 AG009740/AG/NIA NIH HHS/United States ; P01 CA087969/CA/NCI NIH HHS/United States ; MR/N01104X/2/MRC_/Medical Research Council/United Kingdom ; 5R01 CA69669-02/Strategic Research Program in Epidemiology at Karolinska Institute and National Institutes of Health/International ; HHSN261201000006C/CP/NCI NIH HHS/United States ; HHSN268201100004I/HL/NHLBI NIH HHS/United States ; R01 NS049477/NS/NINDS NIH HHS/United States ; R01 CA134958/CA/NCI NIH HHS/United States ; UL1 TR001863/TR/NCATS NIH HHS/United States ; AI076544/NH/NIH HHS/United States ; NS049477/NH/NIH HHS/United States ; 075491/Z/04/Z, and 068545/Z/02/WT_/Wellcome Trust/United Kingdom ; HHSN268201100046C/HL/NHLBI NIH HHS/United States ; NO1-CO-12400/GF/NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; U01 CA167552/CA/NCI NIH HHS/United States ; CA149445/NH/NIH HHS/United States ; R01 ES011740/ES/NIEHS NIH HHS/United States ; R01CA134674/GF/NIH HHS/United States ; R01 AI076544/AI/NIAID NIH HHS/United States ; CA118444/NH/NIH HHS/United States ; R01 CA92153/James R Cerhan is supported by NIH grants/International ; N01 PC067008/PC/NCI NIH HHS/United States ; RR020092/NH/NIH HHS/United States ; HHSN268201100003C/WH/WHI NIH HHS/United States ; R01 CA148690/CA/NCI NIH HHS/United States ; P30 ES000260/ES/NIEHS NIH HHS/United States ; R01 NS067305/NS/NINDS NIH HHS/United States ; UL1 RR024992/RR/NCRR NIH HHS/United States ; C06 RR020092/RR/NCRR NIH HHS/United States ; R01 CA104021/CA/NCI NIH HHS/United States ; R01 ES016813/ES/NIEHS NIH HHS/United States ; K08CA134919/NH/NIH HHS/United States ; R01 CA140561/CA/NCI NIH HHS/United States ; CA186107/NH/NIH HHS/United States ; P30 CA008748/CA/NCI NIH HHS/United States ; MR/N01104X/1/MRC_/Medical Research Council/United Kingdom ; CA104021/NH/NIH HHS/United States ; R01 CA129539/CA/NCI NIH HHS/United States ; R01 CA122663/CA/NCI NIH HHS/United States ; R03 CA150037/CA/NCI NIH HHS/United States ; U58 DP000807/DP/NCCDPHP CDC HHS/United States ; CA49449/NH/NIH HHS/United States ; RR024992 and K23N/S048869/NH/NIH HHS/United States ; R37HL039693/NIH/NHLBI/International ; R01 CA154643/CA/NCI NIH HHS/United States ; P30 CA15083/CA/NCI NIH HHS/United States ; R01 CA062006/CA/NCI NIH HHS/United States ; N01 PC065064/PC/NCI NIH HHS/United States ; K08 CA134919/CA/NCI NIH HHS/United States ; UL1 TR000135/TR/NCATS NIH HHS/United States ; HHSN271201100004C/AG/NIA NIH HHS/United States ; CA92153/NH/NIH HHS/United States ; T32 HG009495/HG/NHGRI NIH HHS/United States ; NS049510/NH/NIH HHS/United States ; R01 CA201407/CA/NCI NIH HHS/United States ; P01CA196569/David Conti is supported by the following NIH/International ; R01 CA098661/CA/NCI NIH HHS/United States ; R01 NS049510/NS/NINDS NIH HHS/United States ; UM1 CA186107/CA/NCI NIH HHS/United States ; HHSN268201100002C/WH/WHI NIH HHS/United States ; P30 CA015083/CA/NCI NIH HHS/United States ; R01 CA092153/CA/NCI NIH HHS/United States ; CA148690/NH/NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; HHSN261201000035C/PC/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; NS43559/NH/NIH HHS/United States ; CIBERESP/Spanish Ministry of Economy and Competitiveness-Carlos III Institute of Health cofunded by FEDER funds/European Regional Develpment Fund (ERDF)-a way to build Europe/International ; HHSN268201100004C, and HHSN271201100004C/National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts/International ; 5P30CA014089/David Conti is supported by the following NIH/International ; UM1 CA167552/CA/NCI NIH HHS/United States ; R37 HL039693/HL/NHLBI NIH HHS/United States ; CA97274/NH/NIH HHS/United States ; N01RC37004/RC/CCR NIH HHS/United States ; R01 CA087014/CA/NCI NIH HHS/United States ; ES000260/ES/NIEHS NIH HHS/United States ; 085475/B/08/Z/WT_/Wellcome Trust/United Kingdom ; P50 CA097274/CA/NCI NIH HHS/United States ; RC2 AG036495/AG/NIA NIH HHS/United States ; WT_/Wellcome Trust/United Kingdom ; HHSN268201100003I/HL/NHLBI NIH HHS/United States ; R01 NS032830/NS/NINDS NIH HHS/United States ; R01 CA049449/CA/NCI NIH HHS/United States ; HHSN268201100002I/HL/NHLBI NIH HHS/United States ; NS26799/NH/NIH HHS/United States ; R21 ES024844/ES/NIEHS NIH HHS/United States ; R01 CA200703/CA/NCI NIH HHS/United States ; N01CO12400/CA/NCI NIH HHS/United States ; 085475/Z/08/Z/WT_/Wellcome Trust/United Kingdom ; R01 NS026799/NS/NINDS NIH HHS/United States ; R01 NS043559/NS/NINDS NIH HHS/United States ; U01 CA049449/CA/NCI NIH HHS/United States ; R01 CA149445/CA/NCI NIH HHS/United States ; P01 CA196569/CA/NCI NIH HHS/United States ; R01 CA134674/CA/NCI NIH HHS/United States ; NS067305/NH/NIH HHS/United States ; P50 CA093459/CA/NCI NIH HHS/United States ; UL1 TR002345/TR/NCATS NIH HHS/United States ; R01 CA045614/CA/NCI NIH HHS/United States ; HHSN261201000026C/CA/NCI NIH HHS/United States ; R01CA206019/David Conti is supported by the following NIH/International ; HHSN268201100001C/WH/WHI NIH HHS/United States ; HHSN268201100004C/WH/WHI NIH HHS/United States ; U01 CA118444/CA/NCI NIH HHS/United States ; P30 CA042014/CA/NCI NIH HHS/United States
• Volume:
  43
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f7f05c06ce86b26c6b55d08bd7338bc90a23e27d5cb55b71aa2c4f50bdcf8b70
• Download URL:
  https://stacks.cdc.gov/view/cdc/94457/cdc_94457_DS1.pdf
• File Type:
  [PDF - 882.34 KB ]