Mucosal melanomas in the racially diverse population of California

Details

• Alternative Title:
  J Am Acad Dermatol
• Personal Author:
  Altieri, Lisa ; Wong, Michael K. ; Peng, David H. ; Cockburn, Myles
• Description:
  Background:
  
  Mucosal melanomas are rare, poorly understood neoplasms without a consensus standard of care.
  
  Objective:
  
  We sought to define mucosal melanoma tumor characteristics and the racial/ethnic attributes of patients with mucosal melanomas.
  
  Methods:
  
  We analyzed 130,920 cutaneous melanomas and 1919 mucosal melanomas recorded in the population-based California Cancer Registry from 1988 to 2013.
  
  Results:
  
  Although only 1% of melanomas occurring in nonHispanic whites were mucosal, other racial/ethnic groups had a higher proportion of mucosal melanomas (15% for Asian/Pacific Islanders, 9% for nonHispanic blacks, and 4% for Hispanics). Anorectal mucosal melanomas were most common in female Asian/Pacific Islanders, whereas genitourinary mucosal melanomas were highest in non-Hispanic whites, and head and neck tumors were most common among Hispanics. Stage at presentation was not uniform among racial/ethnic groups, with Asian/Pacific Islanders having the highest rates of metastasis.
  
  Limitations:
  
  The lack of a standardized staging system for mucosal melanomas confounds classification and knowledge regarding metastasis. Small sample size limits comparative analysis across race, stage, site, and depth.
  
  Conclusion:
  
  Mucosal melanomas differ by race/ethnicity with regard to anatomic site, stage, and depth. Because early detection offers the best chance of increased survival, greater awareness will aid clinicians who care for patients at risk for these aggressive tumors.
  
  
• Subjects:
  Asian Black Or African American Female Hispanic Or Latino Humans Male Melanoma Mucous Membrane Native Hawaiian Or Other Pacific Islander White People
• Source:
  J Am Acad Dermatol. 76(2):250-257
• Pubmed ID:
  27742175
• Pubmed Central ID:
  PMC7491918
• Document Type:
  Journal Article
• Funding:
  HHSN261201000140C/CA/NCI NIH HHS/United States ; P30 CA014089/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035C/PC/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States
• Place as Subject:
  California
• Volume:
  76
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:78962133ceab409902f8e63daaeef9221de1b230d393f63b48a61c3b6eb3f18f
• Download URL:
  https://stacks.cdc.gov/view/cdc/93850/cdc_93850_DS1.pdf
• File Type:
  [PDF - 172.28 KB ]