Details:

Alternative Title:
Am J Transplant
Personal Author:
Anesi, Judith A. ; Han, Jennifer H. ; Lautenbach, Ebbing ; Lee, Dong Heun ; Clauss, Heather ; ... More +
Anesi, Judith A. ; Han, Jennifer H. ; Lautenbach, Ebbing ; Lee, Dong Heun ; Clauss, Heather ; Climaco, Antonette ; Bilker, Warren B. ; Hasz, Richard ; Molnar, Esther ; Alimenti, Darcy ; West, Sharon ; Tolomeo, Pam ; Blumberg, Emily A. Less -
Corporate Authors:
CDC Prevention Epicenters Program
Description:
The extent to which donor multidrug-resistant organisms (MDROs) affect organ utilization remains unclear. We performed a retrospective cohort study at 4 transplant centers between 2015 and 2016 to evaluate this question. All deceased donors who donated at least one organ were included. Exposed donors had at least one MDRO on culture. Unexposed donors had no MDRO-positive cultures. Only cultures obtained during the donor's terminal hospitalization were evaluated. Multivariable regression was used to determine the association between donor MDRO and (1) number of organs transplanted per donor and (2) the match run at which each organ was accepted. Subsequently, we restricted the analysis to donors with MDR-Gram-negative (GN) organisms. Of 440 total donors, 29 (7%) donors grew MDROs and 7 (2%) grew MDR-GNs. There was no significant association between donor MDRO and either measure of organ utilization. However, donor MDR-GNs were associated with a significant reduction in the number of organs transplanted per donor (incidence rate ratio 0.43, 95% confidence interval [CI] 0.39-0.48, P < .01), and organs were accepted significantly further down the match list (relative count 5.08, 95% CI 1.64-15.68, P = .01). Though donor MDR-GNs were infrequent in our study, their growing prevalence could meaningfully reduce the donor pool over time.
Subjects:
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Article Humans Retrospective Studies Tissue And Organ Procurement Tissue Donors Transplants
Source:
Am J Transplant. 20(9):2559-2566
Pubmed ID:
32090413
Pubmed Central ID:
PMC7483863
Document Type:
Journal Article
Funding:
K24 AI080942/AI/NIAID NIH HHSUnited States/ ; UM1 AI104681/AI/NIAID NIH HHSUnited States/ ; U54CK000163/ACL/ACL HHSUnited States/ ; K01 AI137317/AI/NIAID NIH HHSUnited States/ ; K01-AI137317/National Institute of Allergy and Infectious DiseasesInternational/ ; ... More +
K24 AI080942/AI/NIAID NIH HHSUnited States/ ; UM1 AI104681/AI/NIAID NIH HHSUnited States/ ; U54CK000163/ACL/ACL HHSUnited States/ ; K01 AI137317/AI/NIAID NIH HHSUnited States/ ; K01-AI137317/National Institute of Allergy and Infectious DiseasesInternational/ ; FOA#CK000163/CK/NCEZID CDC HHSUnited States/ ; K24-AI080942/National Institute of Allergy and Infectious DiseasesInternational/ ; U54 CK000163/CK/NCEZID CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:40f16a96903069e107d5aed2cf8956aa053e8759e3721f28defd37825ddcd98e
Download URL:
https://stacks.cdc.gov/view/cdc/93503/cdc_93503_DS1.pdf
File Type:

Supporting Files

• 	nihms-1573637.nxml	xml
  	NIHMS1573637-supplement-Supp_info.docx	docx

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