Details:

Alternative Title:
Autism Res
Publisher's site:
http://dx.doi.org/10.1002/aur.2314
Personal Author:
Tian, Lin H. ; Wiggins, Lisa D. ; Schieve, Laura A. ; Yeargin-Allsopp, Marshalyn ; Dietz, Patricia ; ... More +
Tian, Lin H. ; Wiggins, Lisa D. ; Schieve, Laura A. ; Yeargin-Allsopp, Marshalyn ; Dietz, Patricia ; Aylsworth, Arthur S. ; Elias, Ellen R. ; Hoover-Fong, Julie E. ; Meeks, Naomi J. L. ; Souders, Margaret C. ; Tsai, Anne C.-H. ; Zackai, Elaine H. ; Alexander, Aimee A. ; Dowling, Nicole F. ; Shapira, Stuart K. ; Less -
Description:
Previous studies investigating the association between dysmorphology and cognitive, behavioral, and developmental outcomes among individuals with autism spectrum disorder (ASD) have been limited by the binary classification of dysmorphology and lack of comparison groups. We assessed the association using a continuous measure of dysmorphology severity (DS) in preschool children aged 2-5 years (322 with ASD and intellectual disability [ID], 188 with ASD without ID, and 371 without ASD from the general population [POP]). In bivariate analyses, an inverse association between DS and expressive language, receptive language, fine motor, and visual reception skills was observed in children with ASD and ID. An inverse association of DS with fine motor and visual reception skills, but not expressive language and receptive language, was found in children with ASD without ID. No associations were observed in POP children. These results persisted after exclusion of children with known genetic syndromes or major morphologic anomalies. Quantile regression models showed that the inverse relationships remained significant after adjustment for sex, race/ethnicity, maternal education, family income, study site, and preterm birth. DS was not associated with autistic traits or autism symptom severity, behaviors, or regression among children with ASD with or without ID. Thus, DS was associated with a global impairment of cognitive functioning in children with ASD and ID, but only with fine motor and visual reception deficits in children with ASD without ID. A better understanding is needed for mechanisms that explain the association between DS and cognitive impairment in children with different disorders. Autism Res 2020, 13: 1227-1238. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined whether having more dysmorphic features (DFs) was related to developmental problems among children with autism spectrum disorder (ASD) with or without intellectual disability (ID), and children without ASD from the general population (POP). Children with ASD and ID had more language, movement, and learning issues as the number of DFs increased. Children with ASD without ID had more movement and learning issues as the number of DFs increased. These relationships were not observed in the POP group. Implications are discussed.
Subject:
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Article
Autism Spectrum Disorder
Child, Preschool
Cognition
Dysmorphic Features
Dysmorphology Severity
Female
Humans
Intellectual Disability
Male
Neurodevelopment
Premature Birth
Autism Spectrum Disorder
Intellectual Disability

Source:
Autism Res. 13(7):1227-1238 ;
Pubmed ID:
32567802
Pubmed Central ID:
PMC7424904
Document Type:
Journal Article ;
Funding:
U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; ... More +
U10 DD000180/DD/NCBDD CDC HHSUnited States/ ; U10 DD000181/DD/NCBDD CDC HHSUnited States/ ; U10 DD000184/DD/NCBDD CDC HHSUnited States/ ; U01 DD000498/DD/NCBDD CDC HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U10 DD000182/DD/NCBDD CDC HHSUnited States/ ; U10 DD000183/DD/NCBDD CDC HHSUnited States/ ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f88482bac55217e59c4aeaf748df07b50da0b201205cbf4985e0956f40c0b691
File Type:

Supporting Files

• 	nihms-1616795.nxml	xml
  	NIHMS1616795-supplement-Supplemental.docx	docx

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