Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity

Mandage, Rajendra; Kaur, Charandeep; Pramanik, Atreyi; Kumar, Vinod; Kodan, Parul; Singh, Adarsh; Saha, Sounak; Pandey, Shivam; Wig, Naveet; Pandey, Ravindra Mohan; Soneja, Manish; Acharya, Pragyan

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Association of Dengue Virus and Leptospira Co-Infections with Malaria Severity

Supporting Files Public Domain

Aug 2020
By Mandage, Rajendra ; Kaur, Charandeep ; Pramanik, Atreyi ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Mandage, Rajendra ; Kaur, Charandeep ; Pramanik, Atreyi ; Kumar, Vinod ; Kodan, Parul ; Singh, Adarsh ; Saha, Sounak ; Pandey, Shivam ; Wig, Naveet ; Pandey, Ravindra Mohan ; Soneja, Manish ; Acharya, Pragyan
Description:

Plasmodium infections are co-endemic with infections caused by other agents of acute febrile illnesses, such as dengue virus (DENV), chikungunya virus, Leptospira spp., and Orientia tsutsugamushi. However, co-infections may influence disease severity, treatment outcomes, and development of drug resistance. When we analyzed cases of acute febrile illness at the All India Institute of Medical Sciences, New Delhi, India, from July 2017 through September 2018, we found that most patients with malaria harbored co-infections (Plasmodium mixed species and other pathogens). DENV was the most common malaria co-infection (44% of total infections). DENV serotype 4 was associated with mild malaria, and Leptospira was associated with severe malaria. We also found the presence of P. knowlesi in our study population. Therefore, in areas with a large number of severe malaria cases, diagnostic screening for all 4 DENV serotypes, Leptospira, and all Plasmodium species should be performed.
Subjects:

Acute Febrile Illness Association Of Dengue Virus And Leptospira Co-Infections With Malaria Severity Bacteria Co-infection Dengue Leptospira Malaria Microbiology Mild Malaria Orientia Tsutsugamushi Parasites Parasitology Plasmodium Scrub Typhus Severe Malaria Synopsis Viruses
Source:

Emerg Infect Dis. 26(8):1645-1653
Pubmed ID:

32687019
Pubmed Central ID:

PMC7392441
Document Type:

Journal Article
Volume:

26
Issue:

8
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:1a3c882f4155c27788eba118cb3059088b3d9a02550d4843248ec7d9efb2737d
Download URL:

https://stacks.cdc.gov/view/cdc/91527/cdc_91527_DS1.pdf
File Type:

[PDF - 1.05 MB ]

File Language:

English

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