Cancer risk following lymphoid malignancies among HIV-infected people

Details

• Alternative Title:
  AIDS
• Personal Author:
  Mahale, Parag ; Ugoji, Chinenye ; Engels, Eric A. ; Shiels, Meredith S. ; Peprah, Sally ; Morton, Lindsay M.
• Description:
  Objective(s):
  
  HIV-infected people have increased cancer risk. Lymphoma survivors have an increased risk of certain second primary cancers in the general population, but second cancer risk among HIV-infected people is poorly understood. Herein, we characterized the risk of cancers following lymphoid malignancies among HIV-infected people.
  
  Design:
  
  Population-based linkage of HIV and cancer registries.
  
  Methods:
  
  We used data from the US HIV/AIDS Cancer Match Study (1996–2015) and evaluated the risk of first nonlymphoid malignancy in Cox regression models, with first lymphoid malignancy diagnosis as a time-dependent variable.
  
  Results:
  
  Among 531 460 HIV-infected people included in our study, 6513 first lymphoid and 18 944 first nonlymphoid malignancies were diagnosed. Risk of nonlymphoid cancer following a lymphoid malignancy was increased overall [adjusted hazard ratio (aHR) = 2.7; 95% confidence interval (CI) = 2.3–3.2], and specifically for cancers of the oral cavity (aHR = 2.6; 95% CI = 1.2–5.5), colon (2.4; 1.1–5.0), rectum (3.6; 1.9–6.7), anus (3.6; 2.5–5.1), liver (2.0; 1.2–3.5), lung (1.6; 1.1–2.4), vagina/vulva (6.1; 2.3–16.3), and central nervous system (5.0; 1.6–15.6), Kaposi sarcoma (4.6; 3.4–6.2), and myeloid malignancies (9.7; 6.1–15.4). After additional adjustment for prior AIDS diagnosis and time since HIV diagnosis, aHRs were attenuated overall (aHR = 1.7; 95% CI = 1.5–2.0) and remained significant for cancers of the rectum, anus, and vagina/vulva, Kaposi sarcoma, and myeloid malignancies.
  
  Conclusion:
  
  HIV-infected people with lymphoid malignancies have an increased risk of subsequent non-lymphoid cancers. As risks remained significant after adjustment for time since HIV diagnosis and prior AIDS diagnosis, it suggests that immunosuppression may explain some, but not all, of these risks.
  
  
• Subjects:
  Adult Aged AIDS Article Epidemiology Female HIV Infection HIV Infections Humans Incidence Lymphoid Malignancies Lymphoma Male Middle Aged Neoplasms Non-Hodgkin Lymphoma Risk Factors Sarcoma, Kaposi Second Primary Cancers Sexual And Gender Minorities United States

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• Source:
  AIDS. 34(8):1237-1245
• Pubmed ID:
  32287068
• Pubmed Central ID:
  PMC7382023
• Document Type:
  Journal Article
• Funding:
  U58 DP003931/DP/NCCDPHP CDC HHSUnited States/ ; U62 PS004011/PS/NCHHSTP CDC HHSUnited States/ ; HHSN261201300019C/CA/NCI NIH HHSUnited States/ ; U58 DP003919/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP003875/DP/NCCDPHP CDC HHSUnited States/ ; HHSN261201300021C/CA/NCI NIH HHSUnited States/ ; U58 DP003921/DP/NCCDPHP CDC HHSUnited States/ ; F31 CA246855/CA/NCI NIH HHSUnited States/ ; U62 PS001005/PS/NCHHSTP CDC HHSUnited States/ ; U62 PS004001/PS/NCHHSTP CDC HHSUnited States/ ; U58 DP000824/DP/NCCDPHP CDC HHSUnited States/ ; U58 DP003879/DP/NCCDPHP CDC HHSUnited States/ ; U62 PS003960/PS/NCHHSTP CDC HHSUnited States/ ; T32 CA009314/CA/NCI NIH HHSUnited States/ ; HHSN261201300019I/CA/NCI NIH HHSUnited States/
• Volume:
  34
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cb31de981c8da4edd1fdcae63756a395b011fbb5d078f6b817d4d6e9855ea749
• Download URL:
  https://stacks.cdc.gov/view/cdc/91172/cdc_91172_DS1.pdf
• File Type:
  [PDF - 97.58 KB ]